Synergistic antitumour effect of a combination of toremifene and interferon-α on ZR-75-1 human breast cancer cells: Dependence on interferon-α subtype

  • Authors:
    • J. H.J. Martin
    • A. Symonds
  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/or.9.2.379
  • Pages: 379-382
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Abstract

We investigated the effect of toremifene, interferon-α2a, interferon-α2b and interferon-α2c, singly and in combination for their effect on the growth of ZR-75-1 human breast cancer cells. Median effect analysis was used to determine synergistic or additive effects. Anti-proliferative studies showed that the growth of ZR-75-1 cells was inhibited to a greater extent by combination treatment with toremifene plus interferon-α2a, resulting in a synergistic interaction (CI <1) for all concentrations tested. A combination of toremifene plus interferon-α2b resulted in a synergistic interaction (CI <1) for the two highest concentrations of toremifene (10-6 and 10-7 M) and an additive effect (CI approximately equal to 1) for the lower concentrations (10-8 to 10-10 M). When toremifene was combined with interferon-α2c no additive or synergistic interaction was determined.

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March-April 2002
Volume 9 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Martin JH and Martin JH: Synergistic antitumour effect of a combination of toremifene and interferon-α on ZR-75-1 human breast cancer cells: Dependence on interferon-α subtype. Oncol Rep 9: 379-382, 2002
APA
Martin, J.H., & Martin, J.H. (2002). Synergistic antitumour effect of a combination of toremifene and interferon-α on ZR-75-1 human breast cancer cells: Dependence on interferon-α subtype. Oncology Reports, 9, 379-382. https://doi.org/10.3892/or.9.2.379
MLA
Martin, J. H., Symonds, A."Synergistic antitumour effect of a combination of toremifene and interferon-α on ZR-75-1 human breast cancer cells: Dependence on interferon-α subtype". Oncology Reports 9.2 (2002): 379-382.
Chicago
Martin, J. H., Symonds, A."Synergistic antitumour effect of a combination of toremifene and interferon-α on ZR-75-1 human breast cancer cells: Dependence on interferon-α subtype". Oncology Reports 9, no. 2 (2002): 379-382. https://doi.org/10.3892/or.9.2.379