Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer

  • Authors:
    • Geeta Ram Sahu
    • Bijaya Kumar Nayak
    • Srinivas Patnaik
    • Tithi Parija
    • Bibhu Ranjan Das
  • View Affiliations

  • Published online on: March 1, 2002     https://doi.org/10.3892/or.9.2.433
  • Pages: 433-437
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Abstract

The frequency of p53 mutations is low and there is evidence of p53 protein overexpression even without p53 mutations in cervical cancers. This suggests that alternative mechanisms other than p53 mutation could be responsible for tumourigenesis of the uterine cervix. Therefore, an attempt has been made in the present investigation to analyze mutation and rearrangement of p53 gene in primary cervical cancers. The results indicated absence of mutation and presence of rearrangement in about 35% of cervical cancer patients. However, p53 overexpression in 50% of patients was demonstrated by immunohistochemistry and Western blot analysis. Further, rearrangement of p53 has been correlated with p53 mRNA and p53 protein status. The results indicated presence of overexpressed p53 protein in the samples with rearranged p53 gene. Thus, it is presumed that rearrangement of p53 might lead to production of defective p53 protein by affecting the level of p53 protein and this might have a role in the process of tumourigenesis. This study reports for the first time rearrangement of p53 in cervical cancers.

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March-April 2002
Volume 9 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sahu GR, Nayak BK, Patnaik S, Parija T and Das BR: Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer. Oncol Rep 9: 433-437, 2002
APA
Sahu, G.R., Nayak, B.K., Patnaik, S., Parija, T., & Das, B.R. (2002). Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer. Oncology Reports, 9, 433-437. https://doi.org/10.3892/or.9.2.433
MLA
Sahu, G. R., Nayak, B. K., Patnaik, S., Parija, T., Das, B. R."Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer". Oncology Reports 9.2 (2002): 433-437.
Chicago
Sahu, G. R., Nayak, B. K., Patnaik, S., Parija, T., Das, B. R."Rearrangement of p53 gene with overexpressed p53 protein in primary cervical cancer". Oncology Reports 9, no. 2 (2002): 433-437. https://doi.org/10.3892/or.9.2.433