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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease

  • Authors:
    • Nelson Spector
    • Mario Alberto Costa
    • Jose Carlos Morais
    • Irene Biasoli
    • Cristiana Solza
    • Maria De Fatima Gaui
    • Carlos Gil Ferreira
    • Rodrigo Doyle Portugal
    • Monique Loureiro
    • Marcio Nucci
    • Wolmar Pulcheri

  • View Affiliations / Copyright

    Affiliations: Hematology Service, School of Medicine and University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 22461-150, Brazil. spector@ufrj.br
  • Pages: 439-442
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.439
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Abstract

This report describes the results of a multicenter study designed to determine the efficacy and toxicity of a novel combination (ABVP) in patients with newly diagnosed Hodgkin's disease. The ABVP protocol is a modification of ABVD in which prednisone is substituted for DTIC. In order to attempt an increase in drug intensity, doxorubicin, bleomycin and vinblastine were administered on days 1 and 8 of each cycle, and a new cycle began on day 22. Patients who developed phlebitis were allowed to receive the drugs every two weeks. Patients with bulky mediastinal disease received involved field radiation therapy after chemotherapy. Fifty-one patients were treated. Complete remission was achieved in 40 patients (78%). Actuarial failure-free survival in 55 months was 59%, and overall survival was 81%. The overall survival for the 32 patients treated with the intensified regimen was higher than that for those who switched to the bi-weekly schedule (89% vs. 68%, p=0.03). ABVP appears to be equivalent to ABVD. The higher overall survival rate in patients treated every 21 days suggests that this intensified schedule might be more effective. The placement of a Port catheter is recommended, due to the high incidence of phlebitis.

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Copy and paste a formatted citation
Spandidos Publications style
Spector N, Costa MA, Morais JC, Biasoli I, Solza C, De Fatima Gaui M, Ferreira CG, Portugal RD, Loureiro M, Nucci M, Nucci M, et al: Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease. Oncol Rep 9: 439-442, 2002.
APA
Spector, N., Costa, M.A., Morais, J.C., Biasoli, I., Solza, C., De Fatima Gaui, M. ... Pulcheri, W. (2002). Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease. Oncology Reports, 9, 439-442. https://doi.org/10.3892/or.9.2.439
MLA
Spector, N., Costa, M. A., Morais, J. C., Biasoli, I., Solza, C., De Fatima Gaui, M., Ferreira, C. G., Portugal, R. D., Loureiro, M., Nucci, M., Pulcheri, W."Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease". Oncology Reports 9.2 (2002): 439-442.
Chicago
Spector, N., Costa, M. A., Morais, J. C., Biasoli, I., Solza, C., De Fatima Gaui, M., Ferreira, C. G., Portugal, R. D., Loureiro, M., Nucci, M., Pulcheri, W."Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease". Oncology Reports 9, no. 2 (2002): 439-442. https://doi.org/10.3892/or.9.2.439
Copy and paste a formatted citation
x
Spandidos Publications style
Spector N, Costa MA, Morais JC, Biasoli I, Solza C, De Fatima Gaui M, Ferreira CG, Portugal RD, Loureiro M, Nucci M, Nucci M, et al: Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease. Oncol Rep 9: 439-442, 2002.
APA
Spector, N., Costa, M.A., Morais, J.C., Biasoli, I., Solza, C., De Fatima Gaui, M. ... Pulcheri, W. (2002). Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease. Oncology Reports, 9, 439-442. https://doi.org/10.3892/or.9.2.439
MLA
Spector, N., Costa, M. A., Morais, J. C., Biasoli, I., Solza, C., De Fatima Gaui, M., Ferreira, C. G., Portugal, R. D., Loureiro, M., Nucci, M., Pulcheri, W."Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease". Oncology Reports 9.2 (2002): 439-442.
Chicago
Spector, N., Costa, M. A., Morais, J. C., Biasoli, I., Solza, C., De Fatima Gaui, M., Ferreira, C. G., Portugal, R. D., Loureiro, M., Nucci, M., Pulcheri, W."Intensified ABVP chemotherapy for the primary treatment of Hodgkin's disease". Oncology Reports 9, no. 2 (2002): 439-442. https://doi.org/10.3892/or.9.2.439
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