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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2002 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung

  • Authors:
    • N. Yoshida
    • H. Egami
    • J. Yamashita
    • E. Takai
    • Y. Tamori
    • N. Fujino
    • M. Kitaoka
    • J. Schalkwijk
    • M. Ogawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
  • Pages: 495-501
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/or.9.3.495
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Abstract

The immunohistochemical expression of skin-derived anti-leukoproteinase (SKALP)/elafin in lung squamous cell carcinoma (SqCC) and in uninvolved bronchial epithelium was studied. The results were compared with the immunohistochemical staining of proliferating cell nuclear antigen (PCNA) and the TDT-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. SKALP/elafin was expressed in SqCC with high incidence (82.6%). By contrast, the expression was not observed in uninvolved bronchial epithelium. SKALP/elafin expression was located in the cell layers just underneath the cornified envelope of each cell nest, and DNA fragmentation was observed in the same cell layers. PCNA was expressed in the basal layer of each cornified envelope, and both expressions were clearly separated. Immunoreactive score of SKALP/elafin expression was significantly correlated with the differentiation and it tended to increase in accordance with the degree of differentiation. These results suggested that SKALP/elafin was possibly involved in the cell differentiation program, finally leading to keratinization in SqCC of human lung. SKALP/elafin may be a beneficial molecular target for detection or even the development of a new therapeutic method against cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida N, Egami H, Yamashita J, Takai E, Tamori Y, Fujino N, Kitaoka M, Schalkwijk J and Ogawa M: Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung. Oncol Rep 9: 495-501, 2002.
APA
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N. ... Ogawa, M. (2002). Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung. Oncology Reports, 9, 495-501. https://doi.org/10.3892/or.9.3.495
MLA
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N., Kitaoka, M., Schalkwijk, J., Ogawa, M."Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung". Oncology Reports 9.3 (2002): 495-501.
Chicago
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N., Kitaoka, M., Schalkwijk, J., Ogawa, M."Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung". Oncology Reports 9, no. 3 (2002): 495-501. https://doi.org/10.3892/or.9.3.495
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida N, Egami H, Yamashita J, Takai E, Tamori Y, Fujino N, Kitaoka M, Schalkwijk J and Ogawa M: Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung. Oncol Rep 9: 495-501, 2002.
APA
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N. ... Ogawa, M. (2002). Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung. Oncology Reports, 9, 495-501. https://doi.org/10.3892/or.9.3.495
MLA
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N., Kitaoka, M., Schalkwijk, J., Ogawa, M."Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung". Oncology Reports 9.3 (2002): 495-501.
Chicago
Yoshida, N., Egami, H., Yamashita, J., Takai, E., Tamori, Y., Fujino, N., Kitaoka, M., Schalkwijk, J., Ogawa, M."Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung". Oncology Reports 9, no. 3 (2002): 495-501. https://doi.org/10.3892/or.9.3.495
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