search button

Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer

  • Authors:
    • Konosuke Kiuchi
    • Takashi Ishikawa
    • Yohei Hamaguchi
    • Nobuyoshi Momiyama
    • Satoshi Hasegawa
    • Akira Ishiyama
    • Toshiro Kono
    • Takako Doi
    • Takashi Chishima
    • Hiroshi Shimada

  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/or.9.3.595
  • Pages: 595-598
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Bone resorption markers have become available for the diagnosis of bone metastasis. We evaluated cross-linked collagen C-and N-telopeptides (ICTP and NTx) in diagnosing bone metastasis from breast cancer. For a threshold of 4.5 ng/ml of 1CTP and 55.0 pmol BCE/μmol of NTx, bone metastasis could be predicted with an accuracy of 84% and 63%, respectively. All the patients who had metastatic lesions, but showed lower than 4.5 ng/ml of ICTP, had a solitary lesion of bone metastasis. Although ICTP is not sensitive enough to detect an early stage of bone metastasis, it is a better biochemical marker than NTx for detecting bone metastasis from breast cancer.

Related Articles

Journal Cover

May-June 2002
Volume 9 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Kiuchi K, Ishikawa T, Hamaguchi Y, Momiyama N, Hasegawa S, Ishiyama A, Kono T, Doi T, Chishima T, Shimada H, Shimada H, et al: Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer. Oncol Rep 9: 595-598, 2002
APA
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A. ... Shimada, H. (2002). Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer. Oncology Reports, 9, 595-598. https://doi.org/10.3892/or.9.3.595
MLA
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A., Kono, T., Doi, T., Chishima, T., Shimada, H."Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer". Oncology Reports 9.3 (2002): 595-598.
Chicago
Kiuchi, K., Ishikawa, T., Hamaguchi, Y., Momiyama, N., Hasegawa, S., Ishiyama, A., Kono, T., Doi, T., Chishima, T., Shimada, H."Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer". Oncology Reports 9, no. 3 (2002): 595-598. https://doi.org/10.3892/or.9.3.595