The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma

  • Authors:
    • J. Pomp
    • J. Blom
    • M. Linthorst
    • A. H. Zwinderman
    • C. van Krimpen
  • View Affiliations

  • Published online on: May 1, 2002     https://doi.org/10.3892/or.9.3.621
  • Pages: 621-625
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

E-cadherin and the catenins are responsible for inter-cellular adhesion in epithelial tissues. E-cadherin and/or catenin expression is often altered in malignancies, leading to increased invasiveness and metastatic activity of tumour cells. Intact adhesion molecules reduce the risk on distant metastases. This is confirmed by studies mostly performed on surgical series, correlating e-cadherin expression in tumours with prognosis and treatment outcome. It has become more apparent that anti-cancer treatment by itself can also affect the expression of adhesion molecules. We therefore suggest that the prognostic value of e-cadherin expression may depend on the treatment modality and the sequence of therapies administered for malignant tumours. We used paraffin embedded specimens from patients with rectal tumours and patients with laryngeal tumours treated by short course radiotherapy before definitive surgery. Expression of p53, e-cadherin, and β-catenin was determined in pre-radiotherapy biopsies and in the surgical specimens. Material was available from 37 patients. We found no correlation between the expression of p53, e-cadherin or β-catenin and pre-treatment parameters. Mutated p53 in pre-radiation biopsy correlated with increased occurrence of distant metastases and there was an unexpected trend for abnormal e-cadherin expression to correlate with reduced metastases. The prognostic value of p53 no longer existed after examination of the surgical specimens (post-radiotherapy). There was a trend for e-cadherin to reverse from abnormal to normal expression in laryngeal squamous cell carcinomas after radiotherapy, in 5/7 cases it was accompanied with p53 conversion from positive to negative expression. Based on this study it is suggested that the predictive value of the e-cadherin expression for the occurrence of distant metastases in tumours treated by radiotherapy before surgery may be different from that found in tumours treated by surgery only. This may be related to the influence of radiotherapy on e-cadherin expression, especially in squamous cell carcinomas. Alteration in p53 expression was of predictive value only in pre-treatment biopsies and the β-catenin status did not correlate with treatment outcome in this series.

Related Articles

Journal Cover

May-June 2002
Volume 9 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Pomp J, Blom J, Linthorst M, Zwinderman AH and van Krimpen C: The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma. Oncol Rep 9: 621-625, 2002
APA
Pomp, J., Blom, J., Linthorst, M., Zwinderman, A.H., & van Krimpen, C. (2002). The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma. Oncology Reports, 9, 621-625. https://doi.org/10.3892/or.9.3.621
MLA
Pomp, J., Blom, J., Linthorst, M., Zwinderman, A. H., van Krimpen, C."The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma". Oncology Reports 9.3 (2002): 621-625.
Chicago
Pomp, J., Blom, J., Linthorst, M., Zwinderman, A. H., van Krimpen, C."The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma". Oncology Reports 9, no. 3 (2002): 621-625. https://doi.org/10.3892/or.9.3.621