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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-June 2002 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy

  • Authors:
    • Martin B. Steins
    • Hubert Serve
    • Michael Zuhlsdorf
    • Norbert Senninger
    • Michael Semik
    • Wolfgang E. Berdel

  • View Affiliations / Copyright

    Affiliations: Department of Medicine/Haematology and Oncology, University of Muenster, D-48149 Muenster, Germany. steinsm@mednet.uni-muenster.de
  • Pages: 627-630
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/or.9.3.627
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Abstract

Malignant peripheral nerve tumours (MPNT), e.g. malignant schwannoma, represent a relatively rare tumour entity which is usually regarded as a member of the group of soft-tissue sarcomas and treated accordingly. For chemotherapeutic approaches in metastasised disease, ifosfamide and doxorubicin have been identified as the most efficient agents, with overall response rates distinctly less than 50%. In case of non-response, recommendations for effective second-line regimens are lacking. We present the case histories of two patients with pulmonary metastasised MPNT that was primarily refractory to ifosfamide/doxorubicin. Both patients developed a partial remission with tumour reduction exceeding 50% after treatment with carboplatin in combination with etoposide (CE), 150 mg/m2 each, days 1-4 in 4-week intervals. Complete resectability of lung metastases could be achieved, with histologic evidence for advanced tumour regression at the time of resection. Patients remain in stable complete remission 20 and 28 months after surgery, respectively. Major CE-associated toxicity was cumulative myelosuppression, especially thrombocytopenia, reaching WHO grade 4. To our knowledge, this is the first report showing that CE is a possibly successful chemotherapeutic regimen in advanced MPNT, although further studies are necessary to evaluate its efficacy.

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Copy and paste a formatted citation
Spandidos Publications style
Steins MB, Serve H, Zuhlsdorf M, Senninger N, Semik M and Berdel WE: Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy. Oncol Rep 9: 627-630, 2002.
APA
Steins, M.B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., & Berdel, W.E. (2002). Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy. Oncology Reports, 9, 627-630. https://doi.org/10.3892/or.9.3.627
MLA
Steins, M. B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., Berdel, W. E."Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy". Oncology Reports 9.3 (2002): 627-630.
Chicago
Steins, M. B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., Berdel, W. E."Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy". Oncology Reports 9, no. 3 (2002): 627-630. https://doi.org/10.3892/or.9.3.627
Copy and paste a formatted citation
x
Spandidos Publications style
Steins MB, Serve H, Zuhlsdorf M, Senninger N, Semik M and Berdel WE: Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy. Oncol Rep 9: 627-630, 2002.
APA
Steins, M.B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., & Berdel, W.E. (2002). Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy. Oncology Reports, 9, 627-630. https://doi.org/10.3892/or.9.3.627
MLA
Steins, M. B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., Berdel, W. E."Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy". Oncology Reports 9.3 (2002): 627-630.
Chicago
Steins, M. B., Serve, H., Zuhlsdorf, M., Senninger, N., Semik, M., Berdel, W. E."Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy". Oncology Reports 9, no. 3 (2002): 627-630. https://doi.org/10.3892/or.9.3.627
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