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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
May-June 2002 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-June 2002 Volume 9 Issue 3

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Article

Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue

  • Authors:
    • Y. A. Luqmani
    • L. Temmim
    • A. H. Parkar
    • M. Mathew

  • View Affiliations / Copyright

    Affiliations: Kuwait University, Faculty of Pharmacy, Safat 13110, Kuwait. yunus@hsc.kuniv.edu.kw
  • Pages: 645-651
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/or.9.3.645
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Abstract

Cytosol of primary breast cancers from 217 women of predominantly Arab ethnicity were assayed for uPA, tPA, PAI-1 and a subset for ER, PR and pS2. Serum levels of CEA and CA153 were determined during follow-up. Only tPA correlated to nodal status and tumour grade, and PAI-1 to clinical stage. PAI-1 was related to uPA and both were inversely correlated with PR and pS2 (PAI-1 also to ER). Conversely tPA was directly correlated with ER, PR and pS2. Women with high tumour uPA and PAI-1, but not tPA, had shorter overall, and relapse-free, survival. Only nodal status and clinical stage were independent predictors in multivariate analysis. However, uPA and PAI-1 were more prognostically informative than ER or PR and their usefulness may extend to delineation of patients likely to respond to adjuvant therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Luqmani YA, Temmim L, Parkar AH and Mathew M: Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue. Oncol Rep 9: 645-651, 2002.
APA
Luqmani, Y.A., Temmim, L., Parkar, A.H., & Mathew, M. (2002). Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue. Oncology Reports, 9, 645-651. https://doi.org/10.3892/or.9.3.645
MLA
Luqmani, Y. A., Temmim, L., Parkar, A. H., Mathew, M."Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue". Oncology Reports 9.3 (2002): 645-651.
Chicago
Luqmani, Y. A., Temmim, L., Parkar, A. H., Mathew, M."Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue". Oncology Reports 9, no. 3 (2002): 645-651. https://doi.org/10.3892/or.9.3.645
Copy and paste a formatted citation
x
Spandidos Publications style
Luqmani YA, Temmim L, Parkar AH and Mathew M: Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue. Oncol Rep 9: 645-651, 2002.
APA
Luqmani, Y.A., Temmim, L., Parkar, A.H., & Mathew, M. (2002). Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue. Oncology Reports, 9, 645-651. https://doi.org/10.3892/or.9.3.645
MLA
Luqmani, Y. A., Temmim, L., Parkar, A. H., Mathew, M."Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue". Oncology Reports 9.3 (2002): 645-651.
Chicago
Luqmani, Y. A., Temmim, L., Parkar, A. H., Mathew, M."Clinical implications of urokinase and tissue type plasminogen activators and their inhibitor (PAI-1) in breast cancer tissue". Oncology Reports 9, no. 3 (2002): 645-651. https://doi.org/10.3892/or.9.3.645
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