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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2002 Volume 9 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called sequence?

  • Authors:
    • Ken-Ichi Taguchi
    • Yoshiki Asayama
    • Shin-Ichi Aishima
    • Hidehiro Nishi
    • Keishi Sugimachi
    • Shuji Matsuura
    • Takahiro Terashi
    • Takeharu Yamanaka
    • Mitsuo Shimada
    • Keizo Sugimachi
    • Masazumi Tsuneyoshi

  • View Affiliations / Copyright

    Affiliations: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
  • Pages: 737-743
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/or.9.4.737
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Abstract

The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8%) and 35 of type B (31.2%). The frequency of type A in cirrhotic group (74.7%) is statistically higher than that of non-cirrhotic group (54.5%) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.

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Copy and paste a formatted citation
Spandidos Publications style
Taguchi K, Asayama Y, Aishima S, Nishi H, Sugimachi K, Matsuura S, Terashi T, Yamanaka T, Shimada M, Sugimachi K, Sugimachi K, et al: Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncol Rep 9: 737-743, 2002.
APA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S. ... Tsuneyoshi, M. (2002). Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncology Reports, 9, 737-743. https://doi.org/10.3892/or.9.4.737
MLA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9.4 (2002): 737-743.
Chicago
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9, no. 4 (2002): 737-743. https://doi.org/10.3892/or.9.4.737
Copy and paste a formatted citation
x
Spandidos Publications style
Taguchi K, Asayama Y, Aishima S, Nishi H, Sugimachi K, Matsuura S, Terashi T, Yamanaka T, Shimada M, Sugimachi K, Sugimachi K, et al: Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncol Rep 9: 737-743, 2002.
APA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S. ... Tsuneyoshi, M. (2002). Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncology Reports, 9, 737-743. https://doi.org/10.3892/or.9.4.737
MLA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9.4 (2002): 737-743.
Chicago
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9, no. 4 (2002): 737-743. https://doi.org/10.3892/or.9.4.737
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