Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called sequence?

  • Authors:
    • Ken-Ichi Taguchi
    • Yoshiki Asayama
    • Shin-Ichi Aishima
    • Hidehiro Nishi
    • Keishi Sugimachi
    • Shuji Matsuura
    • Takahiro Terashi
    • Takeharu Yamanaka
    • Mitsuo Shimada
    • Keizo Sugimachi
    • Masazumi Tsuneyoshi
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/or.9.4.737
  • Pages: 737-743
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Abstract

The so-called dysplastic nodule-carcinoma sequence in the liver is generally accepted because hepatocellular carcinoma is not an uncommon finding in precancerous lesions. In order to evaluate the existence and frequency of de novo hepatocarcinogenesis we studied 112 surgically resected early well-differentiated hepatocellular carcinomas showing replacing growth without less differentiated component in themselves. They were divided into two groups: carcinoma in dysplastic area (type A) and carcinoma without dysplastic area (type B) and were analyzed clinicopathologically. We encountered 77 cases of type A (68.8%) and 35 of type B (31.2%). The frequency of type A in cirrhotic group (74.7%) is statistically higher than that of non-cirrhotic group (54.5%) (p=0.0453). Using multivariate analysis, the occurrence of type A was related with higher age, the presence of cirrhosis and hepatitis B surface antigen positive. The tumor size and the presence of fatty change in the tumor tended to relate with type A. We propose two pathways morphologically in early hepatocarcinogenesis, one of which has a close relation to hepatitis B virus and/or cirrhosis.

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July-August 2002
Volume 9 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Taguchi K, Asayama Y, Aishima S, Nishi H, Sugimachi K, Matsuura S, Terashi T, Yamanaka T, Shimada M, Sugimachi K, Sugimachi K, et al: Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncol Rep 9: 737-743, 2002
APA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S. ... Tsuneyoshi, M. (2002). Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?. Oncology Reports, 9, 737-743. https://doi.org/10.3892/or.9.4.737
MLA
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9.4 (2002): 737-743.
Chicago
Taguchi, K., Asayama, Y., Aishima, S., Nishi, H., Sugimachi, K., Matsuura, S., Terashi, T., Yamanaka, T., Shimada, M., Sugimachi, K., Tsuneyoshi, M."Morphologic approach to hepatocellular carcinoma development in man: De novo or the so-called <dysplastic nodule-carcinoma> sequence?". Oncology Reports 9, no. 4 (2002): 737-743. https://doi.org/10.3892/or.9.4.737