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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2002 Volume 9 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis

  • Authors:
    • K. Gotte
    • F. Riedel
    • C. Schafer
    • J. F. Coy
    • K. Hormann

  • View Affiliations / Copyright

    Affiliations: Research Laboratory, Department of Otolaryngology, Head and Neck Surgery, University Hospital, Mannheim, D-68135 Mannheim, Germany. karl.goette@hno.ma.uni-heidelberg.de
  • Pages: 829-834
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/or.9.4.829
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Abstract

Very little is known about possible intra-tumoural genetic heterogeneity between primary tumours and lymph node metastases in head and neck squamous cell carcinoma (HNSCC). To investigate this phenomenon, we analysed 96 micro-dissected tumour samples for allelic imbalance at four of the most frequently altered chromosomal locations in HNSCC (3p14.2; 9p21; 11q23.3; 17p13.1) using microsatellite markers. From 23 patients, matched pairs of primary tumour and lymph node metastasis were analysed. Discordance in the allelic distribution was identified in 8 cases (35%). With one exception, the metastasis contained a more balanced allelic status than the primary tumour. In contrast, in a group of 25 tumours with two anatomically different samples from the primary tumour site, discordance was identified in only 3 tumours (13%). These results are compatible with the dissemination of subclones from the primary tumour site with a more balanced allelotype in the metastasis. In our opinion, several scenarios could explain this phenomenon. From a clinical point of view, genetic discordance between the metastasis and the primary tumour must be taken into consideration when establishing molecular biologic markers for choice of therapy and prognosis in head and neck cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Gotte K, Riedel F, Schafer C, Coy JF and Hormann K: Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis. Oncol Rep 9: 829-834, 2002.
APA
Gotte, K., Riedel, F., Schafer, C., Coy, J.F., & Hormann, K. (2002). Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis. Oncology Reports, 9, 829-834. https://doi.org/10.3892/or.9.4.829
MLA
Gotte, K., Riedel, F., Schafer, C., Coy, J. F., Hormann, K."Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis". Oncology Reports 9.4 (2002): 829-834.
Chicago
Gotte, K., Riedel, F., Schafer, C., Coy, J. F., Hormann, K."Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis". Oncology Reports 9, no. 4 (2002): 829-834. https://doi.org/10.3892/or.9.4.829
Copy and paste a formatted citation
x
Spandidos Publications style
Gotte K, Riedel F, Schafer C, Coy JF and Hormann K: Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis. Oncol Rep 9: 829-834, 2002.
APA
Gotte, K., Riedel, F., Schafer, C., Coy, J.F., & Hormann, K. (2002). Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis. Oncology Reports, 9, 829-834. https://doi.org/10.3892/or.9.4.829
MLA
Gotte, K., Riedel, F., Schafer, C., Coy, J. F., Hormann, K."Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis". Oncology Reports 9.4 (2002): 829-834.
Chicago
Gotte, K., Riedel, F., Schafer, C., Coy, J. F., Hormann, K."Genetic discordance between primary tumours and metastases of head and neck cancer detected by microsatellite analysis". Oncology Reports 9, no. 4 (2002): 829-834. https://doi.org/10.3892/or.9.4.829
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