Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma

  • Authors:
    • Yasuhiro Ito
    • Eiji Miyoshi
    • Tsutomu Takeda
    • Masato Sakon
    • Shinji Ihara
    • Masahiko Tsujimoto
    • Nariaki Matsuura
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/or.9.4.853
  • Pages: 853-857
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Abstract

Ets-2, a transcriptional factor, has been linked to carcinoma progression but in-depth studies on its expression in human carcinoma have not been done. The present study investigated ets-2 expression in pancreatic adenocarcinoma. The ets-2 labeling index (LI) in normal pancreatic duct and pancreatic adenocarcinoma averaged 33.1±8.4 and 43.1±18.6, respectively. No statistical significance was found between the LI of normal duct and that of carcinoma with low biological aggressiveness. However, in cases with highly aggressive phenotypes such as stage IV, moderate or poor differentiation, lymph node metastasis, larger size, vascular invasion, lymphatic invasion, perineural invasion, retropancreatic invasion and capsular invasion, the ets-2 LI was significantly higher than in normal ducts and in cases with lower biological aggressiveness. Also, ets-2 transfected pancreatic carcinoma cells, when injected into athymic mice caused the formation of large tumors. These results suggest that ets-2 plays a role in the progression of pancreatic adenocarcinoma predominantly in the late phase.

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July-August 2002
Volume 9 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ito Y, Miyoshi E, Takeda T, Sakon M, Ihara S, Tsujimoto M and Matsuura N: Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma. Oncol Rep 9: 853-857, 2002
APA
Ito, Y., Miyoshi, E., Takeda, T., Sakon, M., Ihara, S., Tsujimoto, M., & Matsuura, N. (2002). Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma. Oncology Reports, 9, 853-857. https://doi.org/10.3892/or.9.4.853
MLA
Ito, Y., Miyoshi, E., Takeda, T., Sakon, M., Ihara, S., Tsujimoto, M., Matsuura, N."Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma". Oncology Reports 9.4 (2002): 853-857.
Chicago
Ito, Y., Miyoshi, E., Takeda, T., Sakon, M., Ihara, S., Tsujimoto, M., Matsuura, N."Ets-2 overexpression contributes to progression of pancreatic adenocarcinoma". Oncology Reports 9, no. 4 (2002): 853-857. https://doi.org/10.3892/or.9.4.853