Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation

Horiike,Norio; Iuchi,Hideto; Ninomiya,Tuneyuki; Kawai,Keiko; Kumagi,Teru; Michitaka,Kojiro; Masumoto,Toshikazu; Onji,Morikazu

doi:10.3892/or.9.5.1059

September-October 2002 Volume 9 Issue 5

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September-October 2002 Volume 9 Issue 5

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Article

Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation

Authors:
- Norio Horiike
- Hideto Iuchi
- Tuneyuki Ninomiya
- Keiko Kawai
- Teru Kumagi
- Kojiro Michitaka
- Toshikazu Masumoto
- Morikazu Onji
View Affiliations / Copyright

Affiliations: Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
Pages: 1059-1062
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Published online on: September 1, 2002

https://doi.org/10.3892/or.9.5.1059
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Abstract

Radiofrequency ablation (RFA), a new local therapy, has recently been developed for hepatocellular carcinoma (HCC). In this study, we have checked for the factors influencing the recurrence of HCC following RFA. We gave special emphasis to complete coagulation. The study population was comprised of 47 patients (80 tumors) with HCC with tumor size of <3 cm in maximal diameter. The patients were observed for a period of 2-3 years (average 865 days). The local recurrence rate was 19% at the end of 1 year, and 21% by the end of 2 years. The patients with local recurrence received significantly fewer RFA sessions (P<0.05) compared to patients with no recurrence. The frequencies of complete coagulation were significantly less (P<0.05) in patients with local recurrence than patients without local recurrence. The distant recurrence rate was 38% at 1 year, and 60% at 2 years. Patients with distant recurrence had significantly increased number of tumors (2.0±1.4) (P<0.05) compared to patients without distant recurrence (1.2±0.4). In conclusion, obtaining complete coagulation is an important factor to prevent local recurrence and the number of tumors predicted the distant recurrence in patients with HCC undergoing RFA.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Influencing factors for recurrence of hepatocellular carcinoma treated with radiofrequency ablation

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