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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2002 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses

  • Authors:
    • M. Volm
    • A. Sauerbrey
    • F. Zintl
    • R. Koomagi
    • T. Efferth
  • View Affiliations / Copyright

    Affiliations: German Cancer Research Center, Heidelberg, Germany
  • Pages: 965-969
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/or.9.5.965
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Abstract

The purpose of this investigation was to evaluate the expression profile of proteins involved in children with newly diagnosed acute lymphoblastic leukemia (ALL) children who are developing relapses. For this reason, the expressions of 10 proteins including proto-oncogene and tumor suppressor gene products, proliferative factors and resistance parameters in 104 initial cases of childhood ALL were analyzed and the proteins correlated with ALL patients who experienced relapses. Applying immunocytochemical assays, we found that 4 out of the 10 parameters revealed a relationship to developing relapses (Fisher's exact tests). These were the oncogene product Fos (p=0.002), the drug resistance proteins glutathione S-transferase (p=0.008) and P-glycoprotein (P-pg/MDR1) (p=0.07) and protein kinase C (p=0.01). By means of hierarchical cluster analysis, we were able to show that the patients could be separated according to their protein expression profile into clusters consisting of patients whose ALL relapsed later and of patients who did not show relapses in the future.

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Copy and paste a formatted citation
Spandidos Publications style
Volm M, Sauerbrey A, Zintl F, Koomagi R and Efferth T: Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses. Oncol Rep 9: 965-969, 2002.
APA
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., & Efferth, T. (2002). Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses. Oncology Reports, 9, 965-969. https://doi.org/10.3892/or.9.5.965
MLA
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., Efferth, T."Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses". Oncology Reports 9.5 (2002): 965-969.
Chicago
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., Efferth, T."Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses". Oncology Reports 9, no. 5 (2002): 965-969. https://doi.org/10.3892/or.9.5.965
Copy and paste a formatted citation
x
Spandidos Publications style
Volm M, Sauerbrey A, Zintl F, Koomagi R and Efferth T: Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses. Oncol Rep 9: 965-969, 2002.
APA
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., & Efferth, T. (2002). Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses. Oncology Reports, 9, 965-969. https://doi.org/10.3892/or.9.5.965
MLA
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., Efferth, T."Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses". Oncology Reports 9.5 (2002): 965-969.
Chicago
Volm, M., Sauerbrey, A., Zintl, F., Koomagi, R., Efferth, T."Protein expression profile of newly diagnosed acute lymphoblastic leukemia in children developing relapses". Oncology Reports 9, no. 5 (2002): 965-969. https://doi.org/10.3892/or.9.5.965
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