Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines

  • Authors:
    • Yuzuru Higuchi
    • Jun-Ichi Asaumi
    • Jun Murakami
    • Toru Wakasa
    • Tetsuyoshi Inoue
    • Masahiro Kuroda
    • Koichi Shibuya
    • Hiroshi Shigehara
    • Shoji Kawasaki
    • Kazuhiro Fukui
    • Kanji Kishi
    • Yoshio Hiraki
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1233
  • Pages: 1233-1236
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Abstract

We reconstructed the recombinant p53-expressing adenovirus and examined its infections and effects in head and neck squamous cell carcinoma cell lines. Eight human head and neck squamous cell carcinoma cell lines were infected by the recombinant adenovirus harboring the lacZ gene (AxCAiLacZ) or the wild-type p53 gene (AxCAip53), and the effects were investigated. The eight cell lines were successfully infected by AxCAiLacZ at a level of more than 50%. The survival of all 8 squamous cell lines were inhibited in the range from 8 to 26.7% by only one treatment of the AxCAip53 infection. This result suggested that p53 gene therapy might become a useful tool in head and neck squamous cell carcinoma treatment.

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November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Higuchi Y, Asaumi J, Murakami J, Wakasa T, Inoue T, Kuroda M, Shibuya K, Shigehara H, Kawasaki S, Fukui K, Fukui K, et al: Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines. Oncol Rep 9: 1233-1236, 2002
APA
Higuchi, Y., Asaumi, J., Murakami, J., Wakasa, T., Inoue, T., Kuroda, M. ... Hiraki, Y. (2002). Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines. Oncology Reports, 9, 1233-1236. https://doi.org/10.3892/or.9.6.1233
MLA
Higuchi, Y., Asaumi, J., Murakami, J., Wakasa, T., Inoue, T., Kuroda, M., Shibuya, K., Shigehara, H., Kawasaki, S., Fukui, K., Kishi, K., Hiraki, Y."Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines". Oncology Reports 9.6 (2002): 1233-1236.
Chicago
Higuchi, Y., Asaumi, J., Murakami, J., Wakasa, T., Inoue, T., Kuroda, M., Shibuya, K., Shigehara, H., Kawasaki, S., Fukui, K., Kishi, K., Hiraki, Y."Adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines". Oncology Reports 9, no. 6 (2002): 1233-1236. https://doi.org/10.3892/or.9.6.1233