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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
November-December 2002 Volume 9 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2002 Volume 9 Issue 6

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Article

Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression

  • Authors:
    • Isao Hara
    • Hideaki Miyake
    • Kazuki Yamanaka
    • Shoji Hara
    • Sadao Kamidono

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, Japan. hara@med.kobe-u.ac.jp
  • Pages: 1379-1383
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/or.9.6.1379
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Abstract

We examined whether serum levels of cathepsin D (CatD) and its density (CatD-D), which was determined by dividing the serum levels of CatD by the prostate volume, could be used as predictors of the progression and prognosis in patients with prostate cancer. Serum levels of CatD in 40 healthy controls, 70 patients with benign prostatic hypertrophy (BPH) and 80 patients with prostate cancer were measured by a sandwich enzyme immunoassay, and prostate volume was measured using transrectal ultrasonography. The mean levels of CatD and CatD-D in patients with prostate cancer were significantly higher than those in healthy controls and patients with BPH. Furthermore, the CatD and CatD-D levels in prostate cancer patients with metastasis were significantly elevated compared with those in patients without metastasis. Among patients who underwent radical prostatectomy, the levels of CatD and CatD-D in patients with pathologically organ-confined disease were significantly lower than in those with extraprostatic disease. However, the elevated levels of CatD and CatD-D were not significantly associated with the cause-specific survival in prostate cancer patients. These findings suggest that the elevation of CatD or CatD-D could be used as new predictors of disease progression, but not prognosis, in patients with prostate cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Hara I, Miyake H, Yamanaka K, Hara S and Kamidono S: Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression. Oncol Rep 9: 1379-1383, 2002.
APA
Hara, I., Miyake, H., Yamanaka, K., Hara, S., & Kamidono, S. (2002). Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression. Oncology Reports, 9, 1379-1383. https://doi.org/10.3892/or.9.6.1379
MLA
Hara, I., Miyake, H., Yamanaka, K., Hara, S., Kamidono, S."Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression". Oncology Reports 9.6 (2002): 1379-1383.
Chicago
Hara, I., Miyake, H., Yamanaka, K., Hara, S., Kamidono, S."Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression". Oncology Reports 9, no. 6 (2002): 1379-1383. https://doi.org/10.3892/or.9.6.1379
Copy and paste a formatted citation
x
Spandidos Publications style
Hara I, Miyake H, Yamanaka K, Hara S and Kamidono S: Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression. Oncol Rep 9: 1379-1383, 2002.
APA
Hara, I., Miyake, H., Yamanaka, K., Hara, S., & Kamidono, S. (2002). Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression. Oncology Reports, 9, 1379-1383. https://doi.org/10.3892/or.9.6.1379
MLA
Hara, I., Miyake, H., Yamanaka, K., Hara, S., Kamidono, S."Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression". Oncology Reports 9.6 (2002): 1379-1383.
Chicago
Hara, I., Miyake, H., Yamanaka, K., Hara, S., Kamidono, S."Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression". Oncology Reports 9, no. 6 (2002): 1379-1383. https://doi.org/10.3892/or.9.6.1379
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