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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2002 Volume 9 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2002 Volume 9 Issue 6

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Article

Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia

  • Authors:
    • Geeta Ram Sahu
    • Bibhu Ranjan Das

  • View Affiliations / Copyright

    Affiliations: Molecular Oncology and Medical Biotechnology Division, Institute of Life Sciences, Chandrasekharpur, Bhubaneswar 751 023, Orissa, India
  • Pages: 1391-1398
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/or.9.6.1391
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Abstract

p53 and Bcl-2 protein accumulation and mutations have been found in a wide variety of cancers including different types of leukemia, with varying frequencies. The objective of our study is to find out the correlation between p53 and Bcl-2 protein expression with respect to overall survival of patient taking clinical features and hematological parameters into consideration. Acute lymphoblastic leukemia (ALL) patients, 100 de novo and 10 relapse, were investigated taking different percentage of stained lymphocytes of patients into consideration. Immunocytochemistry and western blot analysis were used to investigate protein expression. PCR-SSCP technique was used to detect point mutations in exon 5, 6, 7 and 8 of p53 gene. P53 protein expression is of prognostic significance in univariate analysis and when combine with Bcl-2 expression data it provides additional information about overall survival. p53 and Bcl-2 failed to provide additional prognostic information in multivariate analysis. None of the samples shows mutation in exon 5, 6, 7 and 8 of p53 gene. Contrary to previous reports, p53 negativity was associated with lower relapse-free survival. Lower p53 expression was associated with improved disease-free survival. The correlation of p53 and Bcl-2 expression data with respect to clinical outcome may shed new sight into the biological significance of p53/Bcl-2 protein.

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Copy and paste a formatted citation
Spandidos Publications style
Sahu GR and Das BR: Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia. Oncol Rep 9: 1391-1398, 2002.
APA
Sahu, G.R., & Das, B.R. (2002). Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia. Oncology Reports, 9, 1391-1398. https://doi.org/10.3892/or.9.6.1391
MLA
Sahu, G. R., Das, B. R."Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia". Oncology Reports 9.6 (2002): 1391-1398.
Chicago
Sahu, G. R., Das, B. R."Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia". Oncology Reports 9, no. 6 (2002): 1391-1398. https://doi.org/10.3892/or.9.6.1391
Copy and paste a formatted citation
x
Spandidos Publications style
Sahu GR and Das BR: Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia. Oncol Rep 9: 1391-1398, 2002.
APA
Sahu, G.R., & Das, B.R. (2002). Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia. Oncology Reports, 9, 1391-1398. https://doi.org/10.3892/or.9.6.1391
MLA
Sahu, G. R., Das, B. R."Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia". Oncology Reports 9.6 (2002): 1391-1398.
Chicago
Sahu, G. R., Das, B. R."Prognostic significance of p53 and Bcl-2 in acute lymphoblastic leukemia". Oncology Reports 9, no. 6 (2002): 1391-1398. https://doi.org/10.3892/or.9.6.1391
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