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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2008 Volume 20 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 20 Issue 2

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Article

Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China

  • Authors:
    • Yongping Wang
    • Aifeng Wang
    • Rui Jiang
    • Huaxiong Pan
    • Bangxing Huang
    • Yan Lu
    • Cuihuan Wu

  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China
  • Pages: 333-339
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/or_00000011
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Abstract

Infection with specific high-risk human papillomavirus (HPV) types 16 and 18 have been strongly associated with the genesis of various neoplasms in humans, though such study in lung cancer is limited and the results are controversial. In the present study, we collected and explored 313 fresh lung tumor specimens for the presence of HPV with polymerase chain reaction and non-isotopic in situ hybridization. We found that 44.1% of (138/313) non-small cell lung carcinoma (NSCLC) samples were positive for HPV detection, while 4.2% (4/96) of lung benign controls were positive for HPV 16 and 18 DNA. HPV infection was significant between lung squamous cell carcinoma and adenocarcinoma as well as smoking and non-smoking patients. In HPV-positive lung cancer tissues, abnormal p53 protein accumulation was seen in 97 of the 138 carcinomas (70.3%) and expression of pRb in 54 of the 138 carcinomas (39.1%). There was an obvious relationship between the presence of papilloma viral DNA and abnormal p53 protein accumulation and pRb depletion. Cell proliferation and apoptosis were correlated with HPV infection in NSCLC samples. Our data confirm the high prevalence of HPV in lung carcinomas in the central part of China and suggest the possible mechanism of the carcinogenic role of HPV in these carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Wang A, Jiang R, Pan H, Huang B, Lu Y and Wu C: Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncol Rep 20: 333-339, 2008.
APA
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., & Wu, C. (2008). Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncology Reports, 20, 333-339. https://doi.org/10.3892/or_00000011
MLA
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., Wu, C."Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China". Oncology Reports 20.2 (2008): 333-339.
Chicago
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., Wu, C."Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China". Oncology Reports 20, no. 2 (2008): 333-339. https://doi.org/10.3892/or_00000011
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Wang A, Jiang R, Pan H, Huang B, Lu Y and Wu C: Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncol Rep 20: 333-339, 2008.
APA
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., & Wu, C. (2008). Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China. Oncology Reports, 20, 333-339. https://doi.org/10.3892/or_00000011
MLA
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., Wu, C."Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China". Oncology Reports 20.2 (2008): 333-339.
Chicago
Wang, Y., Wang, A., Jiang, R., Pan, H., Huang, B., Lu, Y., Wu, C."Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China". Oncology Reports 20, no. 2 (2008): 333-339. https://doi.org/10.3892/or_00000011
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