mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress

  • Authors:
    • Xiaofeng Zhang
    • Xiaoyan Kang
    • Lehua Shi
    • Jin Li
    • Wen Xu
    • Haihua Qian
    • Mengchao Wu
    • Zhengfeng Yin
  • View Affiliations

  • Published online on: August 1, 2008     https://doi.org/10.3892/or_00000026
  • Pages: 437-442
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Abstract

mda-7/IL-24 shows tumor-suppressor activity in a broad spectrum of human cancer cells. However, the molecular mechanism by which mda-7/IL-24 induces apoptosis is not well understood and most likely involves different pathways depending on the tumor. We examined the apoptotic effect of the adenovirus-mediated mda-7/IL-24 (Ad.mda-7) on human HepG2 hepatoma cells. We found that blocking the endoplasmic reticulum (ER) stress inhibited apoptosis induced by Ad.mda-7 and down-regulated the expression of caspase-12, Bax and caspase-3. The treatment of subcutaneous tumor xenografts of HepG2 cells with Ad.mda-7 inhibited tumor growth and angiogenesis. As in the in vitro studies, we found that blocking ER stress prevented Ad.mda-7 from inducing apoptosis in liver cancer cells in vivo. Our studies suggest that Ad.mda-7 induces apoptosis of HepG2 cells mainly through activation of the ER stress pathway.

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August 2008
Volume 20 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang X, Kang X, Shi L, Li J, Xu W, Qian H, Wu M and Yin Z: mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress. Oncol Rep 20: 437-442, 2008.
APA
Zhang, X., Kang, X., Shi, L., Li, J., Xu, W., Qian, H. ... Yin, Z. (2008). mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress. Oncology Reports, 20, 437-442. https://doi.org/10.3892/or_00000026
MLA
Zhang, X., Kang, X., Shi, L., Li, J., Xu, W., Qian, H., Wu, M., Yin, Z."mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress". Oncology Reports 20.2 (2008): 437-442.
Chicago
Zhang, X., Kang, X., Shi, L., Li, J., Xu, W., Qian, H., Wu, M., Yin, Z."mda-7/IL-24 induces apoptosis in human HepG2 hepatoma cells by endoplasmic reticulum stress". Oncology Reports 20, no. 2 (2008): 437-442. https://doi.org/10.3892/or_00000026