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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats

  • Authors:
    • Yumiko Yasui
    • Shingo Miyamoto
    • Mihye Kim
    • Hiroyuki Kohno
    • Shigeyuki Sugie
    • Takuji Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa 920-0293, Japan. y-yasui@kanazawa-med.ac.jp
  • Pages: 493-499
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000033
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Abstract

We investigated the effects of the two fractions, aqueous (AEP) and ethanolic extracts of propolis (EEP) of the Brazilian propolis on azoxymethane (AOM)-induced aberrant crypt foci (ACF). Male Wistar Hannover (GALAS) rats were administered two weekly subcutaneous injections of AOM (20 mg/kg bw) and fed with diets mixed with AEP (100, 500 and 1,000 ppm) or EEP (500 and 1,000 ppm) for 4 weeks, starting one week before the first dosing of AOM. The modifying effects of the test extracts on ACF formation were assessed by counting the incidence and multiplicity of ACF at week 4. Proliferation cell nuclear antigen (PCNA)-labeling nuclei and apoptotic index were also immunohistochemically determined. Dietary supplementation with AEP and EEP significantly reduced the multiplicity of ACF with the effect of EEP being more potent than AEP. In the ACF and their surrounding non-lesional crypts, significantly lowered cell proliferation was observed in the rats, administered with AOM, and the extracts, while neither fraction affected the apoptotic index. Our findings suggest that AEP and EEP possess a chemopreventive ability in the early phase of colon carcinogenesis through the modulation of cell proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Yasui Y, Miyamoto S, Kim M, Kohno H, Sugie S and Tanaka T: Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats. Oncol Rep 20: 493-499, 2008.
APA
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., & Tanaka, T. (2008). Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats. Oncology Reports, 20, 493-499. https://doi.org/10.3892/or_00000033
MLA
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., Tanaka, T."Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats". Oncology Reports 20.3 (2008): 493-499.
Chicago
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., Tanaka, T."Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats". Oncology Reports 20, no. 3 (2008): 493-499. https://doi.org/10.3892/or_00000033
Copy and paste a formatted citation
x
Spandidos Publications style
Yasui Y, Miyamoto S, Kim M, Kohno H, Sugie S and Tanaka T: Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats. Oncol Rep 20: 493-499, 2008.
APA
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., & Tanaka, T. (2008). Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats. Oncology Reports, 20, 493-499. https://doi.org/10.3892/or_00000033
MLA
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., Tanaka, T."Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats". Oncology Reports 20.3 (2008): 493-499.
Chicago
Yasui, Y., Miyamoto, S., Kim, M., Kohno, H., Sugie, S., Tanaka, T."Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats". Oncology Reports 20, no. 3 (2008): 493-499. https://doi.org/10.3892/or_00000033
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