No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma

  • Authors:
    • N. Charnley
    • R. Airley
    • D. Du Plessis
    • C. West
    • C. Brock
    • C. Barnett
    • J. Matthews
    • K. Symonds
    • M. Bottomly
    • R. Swindell
    • P. Price
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/or_00000039
  • Pages: 537-542
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Abstract

The purpose of this study was to compare glucose metabolism, measured using 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET), with the expression of Glut-1 and -3 and hexokinase I (Hex I) and II in high-grade glioma. The retrospective study involved 27 patients with WHO classification grade III and IV glioma, with either newly diagnosed or recurrent tumours. Patients underwent dynamic and static [18F]FDG-PET to glucose metabolic rate (MRGlu) and standardised uptake value (SUV), respectively. Tumour biopsies were obtained and stained using immunohistochemistry for the expression of Glut-1, -3, Hex I and II. Relationships between variables were studied using Spearman's rank correlation test. Results showed that the expression of Glut-1, Glut-3, Hex I and Hex II varied between and within the tumour samples. The mean of MRGlu was 0.2 (range 0.09-0.25) µmol/min/ml and that of SUV was 4.2 (range 3.2-5.2). There were no significant relationships among the tumour expression of any of the proteins studied with either MRGlu or SUV (p>0.21 for all). In conclusion, the lack of relationship between the immunohistochemical expression of Glut-1, -3, Hex I or II and glucose metabolism measured using [18F]FDG-PET in patients with high-grade glioma may be due to the tissue heterogeneity and presence of necrosis in high-grade tumours.

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September 2008
Volume 20 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Charnley N, Airley R, Du Plessis D, West C, Brock C, Barnett C, Matthews J, Symonds K, Bottomly M, Swindell R, Swindell R, et al: No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma. Oncol Rep 20: 537-542, 2008.
APA
Charnley, N., Airley, R., Du Plessis, D., West, C., Brock, C., Barnett, C. ... Price, P. (2008). No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma. Oncology Reports, 20, 537-542. https://doi.org/10.3892/or_00000039
MLA
Charnley, N., Airley, R., Du Plessis, D., West, C., Brock, C., Barnett, C., Matthews, J., Symonds, K., Bottomly, M., Swindell, R., Price, P."No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma". Oncology Reports 20.3 (2008): 537-542.
Chicago
Charnley, N., Airley, R., Du Plessis, D., West, C., Brock, C., Barnett, C., Matthews, J., Symonds, K., Bottomly, M., Swindell, R., Price, P."No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma". Oncology Reports 20, no. 3 (2008): 537-542. https://doi.org/10.3892/or_00000039