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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article Open Access

Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications

  • Authors:
    • Dario G. Carracedo
    • Aurora Astudillo
    • Juan P. Rodrigo
    • Carlos Suarez
    • Maria Victoria Gonzalez

  • View Affiliations / Copyright

    Affiliations: Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Asturias, Spain
  • Pages: 589-595
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000046
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Abstract

EGFR, p27kip1 and Skp2, have been implicated in human cancer development. We have studied these molecules in a search for molecular markers that may have prognostic value in head and neck squamous cell carcinomas (HNSCC). Tissue samples of 62 patients were collected and immunohistochemical analysis was carried out for p27kip1, Skp2 and EGFR protein evaluation. Western blot analysis of p27kip1 was performed. The p27kip1 expression is frequently down-regulated in HNSCC (44.4%, 20/45 cases). The immunohistochemical analysis showed p27kip1 cytoplasmic retention in 7/38 tumors. Strong Skp2 signals were detected at the invasive edge of the tumor in cells lacking p27kip1 staining. We found a high EGFR staining in 49% (23/47) of the cases. The staining tended to be more frequent in lymph node-positive cases. The dysplastic tissue exhibited no Skp2 immunoreactivity, whereas 51.06% (24/47) of invasive tumors expressed high levels. Of note is that Skp2 overexpression was the only factor that significantly correlated with a shorter overall survival in multivariate analysis (p=0.048). Our results suggest that Skp2 is a useful prognostic marker for HNSCC management.

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Copy and paste a formatted citation
Spandidos Publications style
Carracedo DG, Astudillo A, Rodrigo JP, Suarez C and Gonzalez MV: Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications. Oncol Rep 20: 589-595, 2008.
APA
Carracedo, D.G., Astudillo, A., Rodrigo, J.P., Suarez, C., & Gonzalez, M.V. (2008). Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications. Oncology Reports, 20, 589-595. https://doi.org/10.3892/or_00000046
MLA
Carracedo, D. G., Astudillo, A., Rodrigo, J. P., Suarez, C., Gonzalez, M. V."Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications". Oncology Reports 20.3 (2008): 589-595.
Chicago
Carracedo, D. G., Astudillo, A., Rodrigo, J. P., Suarez, C., Gonzalez, M. V."Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications". Oncology Reports 20, no. 3 (2008): 589-595. https://doi.org/10.3892/or_00000046
Copy and paste a formatted citation
x
Spandidos Publications style
Carracedo DG, Astudillo A, Rodrigo JP, Suarez C and Gonzalez MV: Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications. Oncol Rep 20: 589-595, 2008.
APA
Carracedo, D.G., Astudillo, A., Rodrigo, J.P., Suarez, C., & Gonzalez, M.V. (2008). Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications. Oncology Reports, 20, 589-595. https://doi.org/10.3892/or_00000046
MLA
Carracedo, D. G., Astudillo, A., Rodrigo, J. P., Suarez, C., Gonzalez, M. V."Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications". Oncology Reports 20.3 (2008): 589-595.
Chicago
Carracedo, D. G., Astudillo, A., Rodrigo, J. P., Suarez, C., Gonzalez, M. V."Skp2, p27kip1 and EGFR assessment in head and neck squamous cell carcinoma: Prognostic implications". Oncology Reports 20, no. 3 (2008): 589-595. https://doi.org/10.3892/or_00000046
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