Oral squamous cell carcinomas stimulate osteoclast differentiation

  • Authors:
    • Yoshiaki Deyama
    • Kanchu Tei
    • Yoshitaka Yoshimura
    • Yuri Izumiyama
    • Sadaaki Takeyama
    • Mitsutoki Hatta
    • Yasunori Totsuka
    • Kuniaki Suzuki
  • View Affiliations

  • Published online on: September 1, 2008     https://doi.org/10.3892/or_00000057
  • Pages: 663-668
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Abstract

Matrix metalloproteinases (MMPs) play important roles in the invasion and metastasis to soft tissues of carcinomas including, oral squamous cell carcinomas (SCCs). Although, osteoclastic bone resorption is an important step in bone involvement in a variety of malignancies, the mechanism of bone involvement of oral SCC remains unclear. Once cancer cells arrest in bone, the bone is a storehouse of a variety of cytokines and growth factors and thus provides an extremely fertile environment for cell growth. The bone-invasive oral cancer cell line, BHY, transcriptionally expressed detectable levels of TGF-β, IL-1β, IL-8, parathyroid hormone-related protein (PTHrP) and vascular endothelial growth factor (VEGF) mRNAs and failed to express GM-CSF, IL-6, and TNF-α. Furthermore, the BHY-conditioned medium greatly upregulated IL-6 and RANKL/ODF mRNA expression in osteoblasts, suggesting a potential indirect stimulation of osteoclastogenesis via the osteogenic lineage. Seven out of eleven patients with carcinomas of the lower alveolus and gingiva showing infiltrative bone involvement expressed PTHrP mRNA. These data suggest that the occurrence of PTHrP may be an indication of developing oral malignant carcinomas.

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September 2008
Volume 20 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Deyama Y, Tei K, Yoshimura Y, Izumiyama Y, Takeyama S, Hatta M, Totsuka Y and Suzuki K: Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncol Rep 20: 663-668, 2008
APA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M. ... Suzuki, K. (2008). Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncology Reports, 20, 663-668. https://doi.org/10.3892/or_00000057
MLA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20.3 (2008): 663-668.
Chicago
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20, no. 3 (2008): 663-668. https://doi.org/10.3892/or_00000057