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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2008 Volume 20 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2008 Volume 20 Issue 3

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Article

Oral squamous cell carcinomas stimulate osteoclast differentiation

  • Authors:
    • Yoshiaki Deyama
    • Kanchu Tei
    • Yoshitaka Yoshimura
    • Yuri Izumiyama
    • Sadaaki Takeyama
    • Mitsutoki Hatta
    • Yasunori Totsuka
    • Kuniaki Suzuki

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Cell Pharmacology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan. dey@den.hokudai.ac.jp
  • Pages: 663-668
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/or_00000057
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Abstract

Matrix metalloproteinases (MMPs) play important roles in the invasion and metastasis to soft tissues of carcinomas including, oral squamous cell carcinomas (SCCs). Although, osteoclastic bone resorption is an important step in bone involvement in a variety of malignancies, the mechanism of bone involvement of oral SCC remains unclear. Once cancer cells arrest in bone, the bone is a storehouse of a variety of cytokines and growth factors and thus provides an extremely fertile environment for cell growth. The bone-invasive oral cancer cell line, BHY, transcriptionally expressed detectable levels of TGF-β, IL-1β, IL-8, parathyroid hormone-related protein (PTHrP) and vascular endothelial growth factor (VEGF) mRNAs and failed to express GM-CSF, IL-6, and TNF-α. Furthermore, the BHY-conditioned medium greatly upregulated IL-6 and RANKL/ODF mRNA expression in osteoblasts, suggesting a potential indirect stimulation of osteoclastogenesis via the osteogenic lineage. Seven out of eleven patients with carcinomas of the lower alveolus and gingiva showing infiltrative bone involvement expressed PTHrP mRNA. These data suggest that the occurrence of PTHrP may be an indication of developing oral malignant carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Deyama Y, Tei K, Yoshimura Y, Izumiyama Y, Takeyama S, Hatta M, Totsuka Y and Suzuki K: Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncol Rep 20: 663-668, 2008.
APA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M. ... Suzuki, K. (2008). Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncology Reports, 20, 663-668. https://doi.org/10.3892/or_00000057
MLA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20.3 (2008): 663-668.
Chicago
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20, no. 3 (2008): 663-668. https://doi.org/10.3892/or_00000057
Copy and paste a formatted citation
x
Spandidos Publications style
Deyama Y, Tei K, Yoshimura Y, Izumiyama Y, Takeyama S, Hatta M, Totsuka Y and Suzuki K: Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncol Rep 20: 663-668, 2008.
APA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M. ... Suzuki, K. (2008). Oral squamous cell carcinomas stimulate osteoclast differentiation. Oncology Reports, 20, 663-668. https://doi.org/10.3892/or_00000057
MLA
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20.3 (2008): 663-668.
Chicago
Deyama, Y., Tei, K., Yoshimura, Y., Izumiyama, Y., Takeyama, S., Hatta, M., Totsuka, Y., Suzuki, K."Oral squamous cell carcinomas stimulate osteoclast differentiation". Oncology Reports 20, no. 3 (2008): 663-668. https://doi.org/10.3892/or_00000057
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