Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review)

  • Authors:
    • Suebwong Chuthapisith
    • Jennifer M. Eremin
    • Oleg Eremin
  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/or_00000062
  • Pages: 699-703
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Abstract

The ability to predict the response to neoadjuvant chemotherapy (NAC) prior to or shortly after commencing treatment, in women with large or locally advanced breast cancers, would not only prevent patients from experiencing unnecessary drug morbidity but also reduce the high cost associated with drug usage and utilisation of resources with NAC. Ability to estimate residual cancer volume after NAC is of clinical relevance to subsequent therapeutic surgical options. Various approaches, using conventional histopathological characteristics and imaging modalities to evaluate and predict the response to NAC, have not been able to provide accurate and reliable data. Novel biomolecular imaging, new biomarkers and recent cancer genomic and proteomic profiling, introduced into clinical practice, have produced preliminary promising results. We describe and discuss these molecular characteristics and approaches and their applications to NAC in breast cancer management.

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October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chuthapisith S, Eremin JM and Eremin O: Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review). Oncol Rep 20: 699-703, 2008
APA
Chuthapisith, S., Eremin, J.M., & Eremin, O. (2008). Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review). Oncology Reports, 20, 699-703. https://doi.org/10.3892/or_00000062
MLA
Chuthapisith, S., Eremin, J. M., Eremin, O."Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review)". Oncology Reports 20.4 (2008): 699-703.
Chicago
Chuthapisith, S., Eremin, J. M., Eremin, O."Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review)". Oncology Reports 20, no. 4 (2008): 699-703. https://doi.org/10.3892/or_00000062