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Print ISSN: 1021-335X Online ISSN: 1791-2431
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October 2008 Volume 20 Issue 4

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Predicting response to neoadjuvant chemotherapy in breast cancer: Molecular imaging, systemic biomarkers and the cancer metabolome (Review)

Suebwong Chuthapisith, Jennifer M. Eremin, Oleg Eremin
Pages: 699-703
Published online on: 01 October 2008

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Article

Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastoma cells via paxillin

Naoko Nomura, Motohiro Nomura, Nobuhisa Mizuki, Jun-ichiro Hamada
Pages: 705-711
Published online on: 01 October 2008

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Article

Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma

Wei Li, Dongfeng Tan, Zhaoping Zhang, John J. Liang, Robert E. Brown
Pages: 713-719
Published online on: 01 October 2008

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Article

Lymphangiogenesis in kidney cancer: Expression of VEGF-C, VEGF-D and VEGFR-3 in clear cell and papillary renal cell carcinoma

S. Bierer, E. Herrmann, T. Köpke, J. Neumann, E. Eltze, L. Hertle, C. Wülfing
Pages: 721-725
Published online on: 01 October 2008

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Article

Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats

Michiko Yamamoto, Akinobu Kurita, Takashi Asahara, Akira Takakura, Ken Katono, Maiko Iwasaki, Shinichiro Ryuge, Mayuko Wada, Sayaka Onoda, Tomoko Yanaihara, Masanori Yokoba, Hisashi Mitsufuji, Yasuto Nishii, Tomoya Fukui, Noriyuki Masuda
Pages: 727-730
Published online on: 01 October 2008

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Article

Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs

Antonio Angelini, Manuela Iezzi, Concetta Di Febbo, Carmine Di Ilio, Franco Cuccurullo, Ettore Porreca
Pages: 731-735
Published online on: 01 October 2008

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Article

Liver metastasis of colorectal cancer by protein-tyrosine phosphatase type 4A, 3 (PRL-3) is mediated through lymph node metastasis and elevated serum tumor markers such as CEA and CA19-9

Kazuhiko Hatate, Keishi Yamashita, Kazuya Hirai, Hiroshi Kumamoto, Takeo Sato, Heita Ozawa, Takatoshi Nakamura, Wataru Onozato, Yukihito Kokuba, Atsushi Ihara, Masahiko Watanabe
Pages: 737-743
Published online on: 01 October 2008

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Article

Evaluation of the lateral sentinel node by indocyanine green for rectal cancer based on micrometastasis determined by reverse transcriptase-polymerase chain reaction

Shingo Noura, Masayuki Ohue, Yosuke Seki, Takashi Yamamoto, Atsushi Idota, Junko Fujii, Tomoyuki Yamasaki, Hiromu Nakajima, Kohei Murata, Masao Kameyama, Terumasa Yamada, Isao Miyashiro, Hiroaki Ohigashi, Masahiko Yano, Osamu Ishikawa, Shingi Imaoka
Pages: 745-750
Published online on: 01 October 2008

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Article Open Access

Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: A case control study

Demetrios A. Arvanitis, Demetrios A. Spandidos
Pages: 751-760
Published online on: 01 October 2008

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Article

Relation between serum levels of cell-free DNA and inflammation status in hepatitis C virus-related hepatocellular carcinoma

Michihisa Iida, Norio Iizuka, Isao Sakaida, Toyoki Moribe, Nozomi Fujita, Toshiaki Miura, Shigeru Tamatsukuri, Hideo Ishitsuka, Koichi Uchida, Shuji Terai, Yoshihiro Tokuhisa, Kazuhiko Sakamoto, Takao Tamesa, Takanobu Miyamoto, Yoshihiko Hamamoto, Masaaki Oka
Pages: 761-765
Published online on: 01 October 2008

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Article

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J female mice

Toshiya Kuno, Masanao Yokohira, Yoko Matsuda, Satoshi Suzuki, Nozomi Hashimoto, Keiko Yamakawa, Kousuke Saoo, Katsumi Imaida
Pages: 767-772
Published online on: 01 October 2008

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Article

An unusual p53 mutation detected in Burkitt's lymphoma: 30 bp duplication

Jana Smardova, Diana Grochova, Pavel Fabian, Mojmir Moulis, Jan Smarda, Iva Falkova, Barbora Ravcukova, Jana Vankova, Ingrid Vasova
Pages: 773-778
Published online on: 01 October 2008

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Article

Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors

D. Vallböhmer, H. E. Marcus, S. E. Baldus, J. Brabender, U. Drebber, R. Metzger, A. H. Hölscher, P. M. Schneider
Pages: 779-783
Published online on: 01 October 2008

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Article

Piplartine induces caspase-mediated apoptosis in PC-3 human prostate cancer cells

Eun-Hee Kong, Yun-Jin Kim, Young-Jin Kim, Hyo-Jin Cho, Sun-Nyoung Yu, Kwang-Youn Kim, Jeong-Hyun Chang, Soon-Cheol Ahn
Pages: 785-792
Published online on: 01 October 2008

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Article

Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats

Osamu Kanauchi, Keiichi Mitsuyama, Akira Andoh, Toshihiko Iwanaga
Pages: 793-801
Published online on: 01 October 2008

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Article

Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells

Jun Shi, Yinsheng Wan, Wen Di
Pages: 803-807
Published online on: 01 October 2008

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Article Open Access

Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture

M. Waheed Roomi, Tatiana Kalinovsky, Nusrath W. Roomi, Vadim Ivanov, Matthias Rath, Aleksandra Niedzwiecki
Pages: 809-817
Published online on: 01 October 2008

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Article

Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways

Jian-Li Gao, Jun-Min Shi, Kai He, Qing-Wen Zhang, Shao-Ping Li, Simon Ming-Yuen Lee, Yi-Tao Wang
Pages: 819-824
Published online on: 01 October 2008

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Article

Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization

Eric Roman, Leonardo A. Meza-Zepeda, Stine H. Kresse, Ola Myklebost, Endre N. Vasstrand, Salah O. Ibrahim
Pages: 825-843
Published online on: 01 October 2008

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Article

Co-expression of receptor tyrosine kinases in esophageal adenocarcinoma and squamous cell cancer

Ines Gockel, Markus Moehler, Kirsten Frerichs, Daniel Drescher, Tran Tong Trinh, Friedrich Duenschede, Thomas Borschitz, Katrin Schimanski, Stefan Biesterfeld, Kerstin Herzer, Peter R. Galle, Hauke Lang, Theodor Junginger, Carl C. Schimanski
Pages: 845-850
Published online on: 01 October 2008

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Article

Expression of EGFR and follicular dendritic markers in lymphoid follicles from patients with Castleman's disease

Juhie Lee, Ju Yeon Ban, Kyu Yeoun Won, Gyo-Yong Kim, Sung-Jig Lim, Sun Lee, Youn Wha Kim, Yong-Koo Park, Sang Sook Lee
Pages: 851-856
Published online on: 01 October 2008

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Article

The additional value of integrated PET/CT over PET in initial lymph node staging of esophageal cancer

Hiroyuki Kato, Hitoshi Kimura, Masanobu Nakajima, Makoto Sakai, Akihiko Sano, Naritaka Tanaka, Takanori Inose, Ahmad Faried, Kana Saito, Keisuke Ieta, Makoto Sohda, Yasuyuki Fukai, Tatsuya Miyazaki, Norihiro Masuda, Minoru Fukuchi, Hitoshi Ojima, Katsuhiko Tsukada, Noboru Oriuchi, Keigo Endo, Hiroyuki Kuwano
Pages: 857-862
Published online on: 01 October 2008

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Article

The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases

Kazuya Matsumoto, Takakazu Nagahara, Jun-ichi Okano, Yoshikazu Murawaki
Pages: 863-872
Published online on: 01 October 2008

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Article

Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma

Sebastian Krystian Klosek, Koh-ichi Nakashiro, Shingo Hara, Hiroyuki Goda, Hiroyuki Hamakawa
Pages: 873-878
Published online on: 01 October 2008

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Article

Comparison of cisplatin-paclitaxel combination versus cisplatin-etoposide in patients with small-cell lung cancer: A Phase III study

John Dimitroulis, Angeliki Rapti, George P. Stathopoulos, Sotiris Rigatos, John Stathopoulos, John Koutantos, Athanasios Athanasiadis, Kyriaki Tsikritsaki, Dimitris Karaindros, Kostas Katis, Dimosthenis Antoniou, Michalis Toumbis, Pantelis Giamboudakis
Pages: 879-884
Published online on: 01 October 2008

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Article

Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells

David B. Shennan, Jean Thomson
Pages: 885-889
Published online on: 01 October 2008

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Article

Docetaxel chemotherapy for metastatic hormone refractory prostate cancer as first-line palliative chemotherapy and subsequent re-treatment: Birmingham experience

Jawaher Ansari, Syed Anwer Hussain, Anjali Zarkar, Jacob S. Tanguay, Julie Bliss, John Glaholm
Pages: 891-896
Published online on: 01 October 2008

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Article

Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples

Snezana Vukmirovic-Popovic, Nicholas G. Escott, Wilhelmina C.M. Duivenvoorden
Pages: 897-903
Published online on: 01 October 2008

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Article

Hepatocellular carcinoma-related gene targeting using the large circular antisense library

Kyung-Oh Doh
Pages: 905-911
Published online on: 01 October 2008

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Article

Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma

António E. Pinto, Giovani Silva, Ana Banito, Valeriano Leite, Jorge Soares
Pages: 913-919
Published online on: 01 October 2008

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Article

DNA methylotype analysis in colorectal cancer

Jinsheng Yu, Robert R. Freimuth, Robert Culverhouse, Sharon Marsh, Mark A. Watson, Howard L. McLeod
Pages: 921-927
Published online on: 01 October 2008

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Article

Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells

Guoge Han, Biao Fan, Yimin Zhang, Xuan Zhou, Yongping Wang, Huimin Dong, Yun Wei, Shengrong Sun, Mingbo Hu, Jingwei Zhang, Lei Wei
Pages: 929-939
Published online on: 01 October 2008

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Article Open Access

The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines

Joanna Wietrzyk, Beata Filip, Magdalena Milczarek, Dagmara Klopotowska, Magdalena Maciejewska, Krystyna Dabrowska, Aneta Kurzepa, Stanislaw Dzimira, Janusz Madej, Andrzej Kutner
Pages: 941-952
Published online on: 01 October 2008

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Article

Transformed follicular lymphoma: The 25-year experience of a UK provincial lymphoma treatment centre

N. J. Morley, L. S. Evans, J. Goepel, B. W. Hancock
Pages: 953-956
Published online on: 01 October 2008

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Article

ERK2 CD domain mutation from a human cancer cell line enhanced anchorage-independent cell growth and abnormality in Drosophila

Marthandan Mahalingam, Ramanathan Arvind, Hiroyuki Ida, Avaniyapuram Kannan Murugan, Masamitsu Yamaguchi, Nobuo Tsuchida
Pages: 957-962
Published online on: 01 October 2008

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Article

Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers

Hao Liu, Nanlin Li, Liping Yao, Lei Jiang, Guoqiang Bao, Jipeng Li, Qingjiu Ma, Zhiguo Liu
Pages: 963-969
Published online on: 01 October 2008

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Article

Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells

Esther Dos Santos, Delphine Benaitreau, Marie-Noëlle Dieudonne, Marie-Christine Leneveu, Valérie Serazin, Yves Giudicelli, René Pecquery
Pages: 971-977
Published online on: 01 October 2008

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Article

Identification of tumor-associated antigens in human hepatocellular carcinoma by autoantibodies

Xiaohong Chen, Songbin Fu, Feng Chen, Huanyong Chen, Zhi Chen
Pages: 979-985
Published online on: 01 October 2008

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Article

Triple-negative breast cancer types exhibit a distinct poor clinical characteristic in lymph node-negative Chinese patients

Zhe-Bin Liu, Guang-Yu Liu, Wen-Tao Yang, Gen-Hong Di, Jin-Song Lu, Kun-Wei Shen, Zhen-Zhou Shen, Zhi-Min Shao, Jiong Wu
Pages: 987-994
Published online on: 01 October 2008

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Journal Cover
July-2026 Volume 56 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

Shuqi Zhang, Ping Li, Lixia Zhu
Article Number: 139
Published online on: 28 May 2026

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Review Open Access

Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review)

Mingxing Wu, Mingrong Zhang
Article Number: 138
Published online on: 27 May 2026

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Correction Open Access

[Corrigendum] 17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells

Yu Zuo, Heng Xu, Zhifeng Chen, Fengmin Xiong, Bei Zhang, Kaixian Chen, Hualiang Jiang, Cheng Luo, Hao Zhang
Article Number: 137
Published online on: 27 May 2026

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Review Open Access

Targeting lung cancer with tanshinones: Current mechanistic evidence and emerging opportunities (Review)

Zhengqi Guo, Xiaoci Li, Pengyu Suo, Zhanyu Lin, Ruixin Liu, Chenyu Chi
Article Number: 136
Published online on: 26 May 2026

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Review Open Access

Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review)

Fei Qu, Jiale Tong, Weiwei Qian, Qian He
Article Number: 135
Published online on: 26 May 2026

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Correction Open Access

[Corrigendum] Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression

Lei Zhu, Xiao-Xia Li, Liang Shi, Jing Wu, Jia-Yi Qian, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Article Number: 134
Published online on: 20 May 2026

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Review Open Access

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)

Yuanbo Xu, Weili Wang, Yating Zhang, Yinqiu Fan, Wanying Dong, Jun Yang
Article Number: 133
Published online on: 20 May 2026

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Retraction Open Access

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway

Xiong Shu, Huiqi Liu, Rui Zhen, Yongsheng Jie, Lei Chen, Hui Qi, Chao Wang, Renxian Wang, Dafu Chen, Yuliang Ran
Article Number: 132
Published online on: 18 May 2026

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Article Open Access

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway

Huili Feng, Lixin He, Talha Umar, Haipeng Wang, Yanling Gao, Gongyi Chen, Panfeng Sun, Ling Yin, Wenbin Zhao, Huifang Lu, Ganzhen Deng, Changwei Qiu
Article Number: 131
Published online on: 14 May 2026

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Correction Open Access

[Corrigendum] ENO2 affects the EMT process of renal cell carcinoma and participates in the regulation of the immune micro­environment

Wei-Jie Chen, Wei Yang, Min Gong, Yi He, Da Xu, Jia-Xin Chen, Wen-Jin Chen, Wen-Yan Li, Yu-Qi Wang, Ke-Qin Dong, Xu Song, Xiu-Wu Pan, Xin-Gang Cui
Article Number: 130
Published online on: 13 May 2026

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Article Open Access

SRRT promotes prostate cancer progression and serves as a prognostic biomarker through STAT3 pathway activation

Lingxiang Lu, Ke Wu, Zhenfan Wang, Ruoxi Yang, Kai Li, Shuai Guo, Fei Wang, Zheng Ma
Article Number: 129
Published online on: 13 May 2026

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Retraction Open Access

[Retracted] Hsp72 controls bortezomib‑induced HepG2 cell death via interaction with pro‑apoptotic factors 

Giuseppe Calvaruso, Michela Giuliano, Patrizia Portanova, Ornella Pellerito, Renza Vento, Giovanni Tesoriere
Article Number: 128
Published online on: 11 May 2026

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Article Open Access

Effect of the miR‑26a/b‑5p‑STAT3‑YKL‑40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells

Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan
Article Number: 127
Published online on: 08 May 2026

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Review Open Access

Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review)

Hongyan Li, Shiyuan Song, Linlin Wang, Qiang Liu
Article Number: 126
Published online on: 08 May 2026

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Article Open Access

A novel regulatory role of microRNA‑5590‑3p in hepatocellular carcinoma via the HOXB2/MYC axis

Bin Li, Lin Zhou
Article Number: 125
Published online on: 07 May 2026

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Retraction Open Access

[Retracted] SHIP1 is targeted by miR‑155 in acute myeloid leukemia

Hua Xue, Luo-Ming Hua, Ming Guo, Jian-Min Luo
Article Number: 124
Published online on: 05 May 2026

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Review Open Access

Chronic stress and cancer progression through neuro‑endocrine‑immune networks (Review)

Zhangxiang Zhu, Xiaohu Zhang, Jing Yan, Mingquan Wang, Yang Lv, Wuqiong Zhang, Hui Guo, Aimei Zheng
Article Number: 123
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Article Number: 122
Published online on: 29 April 2026

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August-2026 Volume 56 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review)

Qing Liu, Rui Wang, Zhenbo Li, Yihan Liu, Lei Wu, Yuqin Zhao, Jing Yang
Article Number: 144
Published online on: 04 June 2026

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Review Open Access

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review)

Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai
Article Number: 143
Published online on: 03 June 2026

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Review Open Access

Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review)

Qiangzong Yu, Pengbo Luan, Jingru Liang, Lixin Wang
Article Number: 142
Published online on: 02 June 2026

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Expression of Concern Open Access

[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao, Guohua Li, Yu You, Hongping Wan, Qiong Wu, Chongwen Wang, Nonghua Lv
Article Number: 141
Published online on: 02 June 2026

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Article Open Access

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer

Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen
Article Number: 140
Published online on: 29 May 2026

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