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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors

  • Authors:
    • D. Vallböhmer
    • H. E. Marcus
    • S. E. Baldus
    • J. Brabender
    • U. Drebber
    • R. Metzger
    • A. H. Hölscher
    • P. M. Schneider

  • View Affiliations / Copyright

    Affiliations: Department of Visceral and Vascular Surgery, University of Cologne, Cologne, Germany
  • Pages: 779-783
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000074
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Abstract

Predicting the malignant potential of gastrointestinal stromal tumors (GISTs) remains difficult. We assessed the value of serosal penetration, an established prognostic factor in solid tumors, to determine the clinical outcome in patients with GISTs. From 1996-2002, 25 consecutive patients with GIST underwent surgical resection at our Department. The histopathological presence of serosal penetration was assessed to predict clinical outcome. In addition, the established histopathological classification system by Franquemont (modified by using the Ki-67 proliferation index), was applied to each study patient. A Ki-67 index ≥5% (p<0.001) and a mitotic rate ≥5/50 high-power fields (p<0.047) significantly correlated with a shorter survival, whereas a tumor size >5 cm (p=0.07) tended towards a worse prognosis. The survival of patient groups defined by Franquemont (p=0.03) were of prognostic relevance. The presence of serosal penetration significantly correlated (p<0.01) with a shorter survival. Our data suggest that the presence of serosal penetration is a negative prognostic factor for GISTs. Serosal penetration may become a useful additional parameter for the classification of the malignant potential of GISTs. Since our data are merely hypothesis-generating, serosal penetration should be evaluated in large prospective databases.

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Copy and paste a formatted citation
Spandidos Publications style
Vallböhmer D, Marcus HE, Baldus SE, Brabender J, Drebber U, Metzger R, Hölscher AH and Schneider PM: Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors. Oncol Rep 20: 779-783, 2008.
APA
Vallböhmer, D., Marcus, H.E., Baldus, S.E., Brabender, J., Drebber, U., Metzger, R. ... Schneider, P.M. (2008). Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors. Oncology Reports, 20, 779-783. https://doi.org/10.3892/or_00000074
MLA
Vallböhmer, D., Marcus, H. E., Baldus, S. E., Brabender, J., Drebber, U., Metzger, R., Hölscher, A. H., Schneider, P. M."Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors". Oncology Reports 20.4 (2008): 779-783.
Chicago
Vallböhmer, D., Marcus, H. E., Baldus, S. E., Brabender, J., Drebber, U., Metzger, R., Hölscher, A. H., Schneider, P. M."Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors". Oncology Reports 20, no. 4 (2008): 779-783. https://doi.org/10.3892/or_00000074
Copy and paste a formatted citation
x
Spandidos Publications style
Vallböhmer D, Marcus HE, Baldus SE, Brabender J, Drebber U, Metzger R, Hölscher AH and Schneider PM: Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors. Oncol Rep 20: 779-783, 2008.
APA
Vallböhmer, D., Marcus, H.E., Baldus, S.E., Brabender, J., Drebber, U., Metzger, R. ... Schneider, P.M. (2008). Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors. Oncology Reports, 20, 779-783. https://doi.org/10.3892/or_00000074
MLA
Vallböhmer, D., Marcus, H. E., Baldus, S. E., Brabender, J., Drebber, U., Metzger, R., Hölscher, A. H., Schneider, P. M."Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors". Oncology Reports 20.4 (2008): 779-783.
Chicago
Vallböhmer, D., Marcus, H. E., Baldus, S. E., Brabender, J., Drebber, U., Metzger, R., Hölscher, A. H., Schneider, P. M."Serosal penetration is an important prognostic factor for gastrointestinal stromal tumors". Oncology Reports 20, no. 4 (2008): 779-783. https://doi.org/10.3892/or_00000074
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