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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 20 Issue 4

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Article

Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples

  • Authors:
    • Snezana Vukmirovic-Popovic
    • Nicholas G. Escott
    • Wilhelmina C.M. Duivenvoorden

  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Molecular Medicine, McMaster University, Ontario L8N 3Z5, Canada
  • Pages: 897-903
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000089
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Abstract

Patients with advanced prostate cancer frequently have a poor prognosis as a result of metastasis. The serum prostate-specific antigen (PSA) test is widely used for the diagnosis of prostate cancer. The enzymatic activity of PSA may be involved in the invasion of prostate cancer. We set out to determine the prevalent form of PSA in human prostate adenocarcinoma samples by ELISA and Western blot analysis and its enzymatic activity using a synthetic substrate S-2586 and fibronectin. Our results show that in serum from prostate cancer patients and in tumour homogenates, the prevalent form was PSA bound to α1-antichymotrypsin. All homogenates showed enzymatic activity towards a synthetic PSA substrate, whereas only five samples showed activity at 28 kDa towards fibronectin as determined by enzymography, which is most likely due to active PSA. Human prostate cancer LNCaP cells produced largely inactive PSA. In comparison, 22Rv1 cells produced 29-fold less PSA, but with high specific activity. Similarly, our results from the human prostate cancer tissue samples also show that free PSA appears to exist in diverse forms of very different specific activity. Since PSA, as a serine protease, may be involved in the invasion of prostate cancer, our results suggest that prostate cancers have potentially diverse invasive capacity due to differences in specific enzymatic activity of PSA.

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Copy and paste a formatted citation
Spandidos Publications style
Vukmirovic-Popovic S, Escott NG and Duivenvoorden WC: Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples. Oncol Rep 20: 897-903, 2008.
APA
Vukmirovic-Popovic, S., Escott, N.G., & Duivenvoorden, W.C. (2008). Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples. Oncology Reports, 20, 897-903. https://doi.org/10.3892/or_00000089
MLA
Vukmirovic-Popovic, S., Escott, N. G., Duivenvoorden, W. C."Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples". Oncology Reports 20.4 (2008): 897-903.
Chicago
Vukmirovic-Popovic, S., Escott, N. G., Duivenvoorden, W. C."Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples". Oncology Reports 20, no. 4 (2008): 897-903. https://doi.org/10.3892/or_00000089
Copy and paste a formatted citation
x
Spandidos Publications style
Vukmirovic-Popovic S, Escott NG and Duivenvoorden WC: Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples. Oncol Rep 20: 897-903, 2008.
APA
Vukmirovic-Popovic, S., Escott, N.G., & Duivenvoorden, W.C. (2008). Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples. Oncology Reports, 20, 897-903. https://doi.org/10.3892/or_00000089
MLA
Vukmirovic-Popovic, S., Escott, N. G., Duivenvoorden, W. C."Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples". Oncology Reports 20.4 (2008): 897-903.
Chicago
Vukmirovic-Popovic, S., Escott, N. G., Duivenvoorden, W. C."Presence and enzymatic activity of prostate-specific antigen in archival prostate cancer samples". Oncology Reports 20, no. 4 (2008): 897-903. https://doi.org/10.3892/or_00000089
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