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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article Open Access

The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines

  • Authors:
    • Joanna Wietrzyk
    • Beata Filip
    • Magdalena Milczarek
    • Dagmara Klopotowska
    • Magdalena Maciejewska
    • Krystyna Dabrowska
    • Aneta Kurzepa
    • Stanislaw Dzimira
    • Janusz Madej
    • Andrzej Kutner

  • View Affiliations / Copyright

    Affiliations: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland. wietrzyk@iitd.pan.wroc.pl
  • Pages: 941-952
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000094
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Abstract

Integrins are cell-surface receptors engaged in important cancer invasion processes, such as adhesion, migration, proliferation and differentiation. The aim of this study was to evaluate the effect of 1,25-dihydroxyvitamin D3 (calcitriol) and its metabolite 1,24-dihydroxyvitamin D3 (PRI-2191) on αvβ3 integrin expression in various cancer cell lines. The expression levels of the β3 and αv integrins were reduced only in the WEHI-3 and LLC cell lines by the two compounds. Calcitriol or PRI-2191 treatment caused differentiation of WEHI-3 mouse leukemia cells, but apoptosis of LLC cells. WEHI-3 and LLC cells exposed to calcitriol or PRI-2191 lost their migratory and adhesive potentials. The inhibition of migratory potential was higher in the LLC cells than in the WEHI-3 cells and appeared to correlate with the increased down-regulation of αvβ3 integrin by calcitriol or PRI-2191. The observed in vivo effects (antitumor and antimetastatic) in mice bearing subcutaneously transplanted LLC cancer are possibly associated with inhibited migratory potential as a consequence of the lowered integrin expression caused by calcitriol or PRI-2191.

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Copy and paste a formatted citation
Spandidos Publications style
Wietrzyk J, Filip B, Milczarek M, Klopotowska D, Maciejewska M, Dabrowska K, Kurzepa A, Dzimira S, Madej J, Kutner A, Kutner A, et al: The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncol Rep 20: 941-952, 2008.
APA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K. ... Kutner, A. (2008). The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncology Reports, 20, 941-952. https://doi.org/10.3892/or_00000094
MLA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20.4 (2008): 941-952.
Chicago
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20, no. 4 (2008): 941-952. https://doi.org/10.3892/or_00000094
Copy and paste a formatted citation
x
Spandidos Publications style
Wietrzyk J, Filip B, Milczarek M, Klopotowska D, Maciejewska M, Dabrowska K, Kurzepa A, Dzimira S, Madej J, Kutner A, Kutner A, et al: The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncol Rep 20: 941-952, 2008.
APA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K. ... Kutner, A. (2008). The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines. Oncology Reports, 20, 941-952. https://doi.org/10.3892/or_00000094
MLA
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20.4 (2008): 941-952.
Chicago
Wietrzyk, J., Filip, B., Milczarek, M., Klopotowska, D., Maciejewska, M., Dabrowska, K., Kurzepa, A., Dzimira, S., Madej, J., Kutner, A."The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on αvβ3 integrin expression in cancer cell lines". Oncology Reports 20, no. 4 (2008): 941-952. https://doi.org/10.3892/or_00000094
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