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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2008 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2008 Volume 20 Issue 4

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Article

Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers

  • Authors:
    • Hao Liu
    • Nanlin Li
    • Liping Yao
    • Lei Jiang
    • Guoqiang Bao
    • Jipeng Li
    • Qingjiu Ma
    • Zhiguo Liu

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, P.R. China
  • Pages: 963-969
    |
    Published online on: October 1, 2008
       https://doi.org/10.3892/or_00000097
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Abstract

Chemotherapy is the standard treatment for patients with advanced gastric cancer; however, it has been difficult to predict chemotherapy response. In the current study, we attempted to develop a prediction model for individual response to doxorubicin chemotherapy in gastric cancer patients based on the hypothesis that expression analysis of a set of key drug sensitivity genes for doxorubicin could allow us to predict therapeutic response. From literature and our previous microarray data, the genes correlative in the expression levels with doxorubicin response were chosen. We selected seven reliable prediction markers for doxorubicin from 90 candidate sequences. Using expression data of genes quantified by real-time reverse transcription-PCR in 20 specimens, we fixed a linear model by multiple regressions, which converted the quantified expression data into a calculated inhibition rate of doxorubicin. Using the same set of genes, we then validated the formula in an independent set of 19 specimens. Our results suggest that the response of gastric cancer to doxorubicin can be predicted by expression patterns in this set of genes. The response prediction model will be of practical use to evaluate patient before chemotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Li N, Yao L, Jiang L, Bao G, Li J, Ma Q and Liu Z: Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers. Oncol Rep 20: 963-969, 2008.
APA
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J. ... Liu, Z. (2008). Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers. Oncology Reports, 20, 963-969. https://doi.org/10.3892/or_00000097
MLA
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J., Ma, Q., Liu, Z."Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers". Oncology Reports 20.4 (2008): 963-969.
Chicago
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J., Ma, Q., Liu, Z."Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers". Oncology Reports 20, no. 4 (2008): 963-969. https://doi.org/10.3892/or_00000097
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Li N, Yao L, Jiang L, Bao G, Li J, Ma Q and Liu Z: Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers. Oncol Rep 20: 963-969, 2008.
APA
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J. ... Liu, Z. (2008). Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers. Oncology Reports, 20, 963-969. https://doi.org/10.3892/or_00000097
MLA
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J., Ma, Q., Liu, Z."Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers". Oncology Reports 20.4 (2008): 963-969.
Chicago
Liu, H., Li, N., Yao, L., Jiang, L., Bao, G., Li, J., Ma, Q., Liu, Z."Prediction of doxorubicin sensitivity in gastric cancers based on a set of novel markers". Oncology Reports 20, no. 4 (2008): 963-969. https://doi.org/10.3892/or_00000097
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