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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 20 Issue 5

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Article

Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation

  • Authors:
    • Xiaojun Ding
    • Jian Sun
    • Lizhen Wang
    • Guolin Li
    • Yi Shen
    • Xiaojian Zhou
    • Wantao Chen

  • View Affiliations / Copyright

    Affiliations: Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, The 9th People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China
  • Pages: 1041-1045
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000107
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Abstract

Small ubiquitin-like modifiers (SUMOs) play an important role in tumors. The SUMOylation can be reversed by SUMO-specific proteases (SENPs). As one of the crucial members of the SUMO system, SENP5 is essential in mitosis and/or cytokinesis. In the present study, we analyzed the expression of SENP5 in human oral squamous cell carcinoma and investigated the relationship between its expression level and clinicopathological parameters. Expression levels of SENP5 in 48 patients with oral squamous cell carcinoma were investigated by immunohistochemistry. Immunoreactivity was evaluated semiquantitatively using German immunoreactive score (IRS). The relationship between SENP5 expression status and the clinical and pathological characteristics of patients was analyzed and survival curves were calculated using the Kaplan-Meier method and log-rank tests. We found that SENP5 predominantly localized to cytoplasm of OSCC cells and the expression of SENP5 in OSCC is not the same as in paracarcinoma epithelia. The SENP5 expression status was associated with differentiation of OSCC and not with any other clinicopathological parameters. These findings suggest altered subcellular localization of SENP5 in OSCC cells and the correlation between SENP5 expression and the differentiation of OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Ding X, Sun J, Wang L, Li G, Shen Y, Zhou X and Chen W: Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 20: 1041-1045, 2008.
APA
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., & Chen, W. (2008). Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncology Reports, 20, 1041-1045. https://doi.org/10.3892/or_00000107
MLA
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., Chen, W."Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 20.5 (2008): 1041-1045.
Chicago
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., Chen, W."Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 20, no. 5 (2008): 1041-1045. https://doi.org/10.3892/or_00000107
Copy and paste a formatted citation
x
Spandidos Publications style
Ding X, Sun J, Wang L, Li G, Shen Y, Zhou X and Chen W: Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 20: 1041-1045, 2008.
APA
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., & Chen, W. (2008). Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation. Oncology Reports, 20, 1041-1045. https://doi.org/10.3892/or_00000107
MLA
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., Chen, W."Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 20.5 (2008): 1041-1045.
Chicago
Ding, X., Sun, J., Wang, L., Li, G., Shen, Y., Zhou, X., Chen, W."Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation". Oncology Reports 20, no. 5 (2008): 1041-1045. https://doi.org/10.3892/or_00000107
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