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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November 2008 Volume 20 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article

Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer

Riyad Bendardaf, Hanan Lamlum, Raija Ristamäki, Kari Syrjänen, Seppo Pyrhönen
Pages: 999-1004
Published online on: 01 November 2008

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Article

Expression of orotate phosphoribosyltransferase in colorectal carcinoma: An immunohistochemical analysis in several components of neoplastic lesions

Yuichi Sanada, Kazuhiro Yoshida, Jun Hihara, Morihito Okada
Pages: 1005-1011
Published online on: 01 November 2008

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Article

Positive KL-6 mucin expression combined with decreased membranous β-catenin expression indicates worse prognosis in colorectal carcinoma

Wei Zhang, Wei Tang, Yoshinori Inagaki, Ming Qiu, Huan-Li Xu, Xun Li, Yasuhiko Sugawara, Hirokazu Nagawa, Munehiro Nakata, Norihiro Kokudo
Pages: 1013-1019
Published online on: 01 November 2008

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Article

Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus

Atsushi Yamada, Hiroki Sasaki, Kazuhiko Aoyagi, Masayuki Sano, Satoshi Fujii, Hiroyuki Daiko, Mitsuyo Nishimura, Teruhiko Yoshida, Tsutomu Chiba, Atsushi Ochiai
Pages: 1021-1027
Published online on: 01 November 2008

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Article

The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1

Ioannis Panagopoulos, Emely Möller, Anna Collin, Fredrik Mertens
Pages: 1029-1033
Published online on: 01 November 2008

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Article

Potent anti-hepatoma efficacy of HCCS1 via dual tumor-targeting gene-virotherapy strategy

Jian Zhang, Yu Gan, Jinfa Gu, Jingying Hu, Xinyuan Liu, Xintai Zhao
Pages: 1035-1040
Published online on: 01 November 2008

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Article

Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiation

Xiaojun Ding, Jian Sun, Lizhen Wang, Guolin Li, Yi Shen, Xiaojian Zhou, Wantao Chen
Pages: 1041-1045
Published online on: 01 November 2008

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Article

DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment

Takeshi Yuki, Yoshimasa Maniwa, Takefumi Doi, Kenji Okada, Wataru Nishio, Yoshitake Hayashi, Yutaka Okita
Pages: 1047-1052
Published online on: 01 November 2008

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Article

Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells

Shu Huang, Faming Zhang, Lin Miao, Huijie Zhang, Zhining Fan, Xuehao Wang, Guozhong Ji
Pages: 1053-1059
Published online on: 01 November 2008

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Article

CpG island methylation status in the EpCAM promoter region and gene expression

Guolong Yu, Xiangzhong Zhang, Huaqiao Wang, Derong Rui, Aihua Yin, Geng Qiu, Yunshao He
Pages: 1061-1067
Published online on: 01 November 2008

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Article

The expression and the functional roles of tissue factor and protease-activated receptor-2 on SW620 cells

Hong Zhou, Hongxin Hu, Wenxia Shi, Shucai Ling, Ting Wang, Haibo Wang
Pages: 1069-1076
Published online on: 01 November 2008

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Article

LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma

Yu Yang, Hua Yang, Michael A. McNutt, Fuxia Xiong, Xiu Nie, Li Li, Rouli Zhou
Pages: 1077-1083
Published online on: 01 November 2008

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Article

The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis

Shanghui Zhou, Lili Li, Xinchun Jian, Xinrong Ou, Haiying Jiang, Zhigang Yao, Chunjiao Xu, Jieying Peng
Pages: 1085-1091
Published online on: 01 November 2008

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Article

Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

Bai-Li Chen, Jun Yu, Zhi-Rong Zeng, Wai-Kit Chu, Christine Y.P. Wong, Yuen-Yee Cheng, Joseph J.Y. Sung, Pin-Jin Hu, Wai K. Leung
Pages: 1093-1097
Published online on: 01 November 2008

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Article

Potential chemoprevention effect of dietary fucoxanthin on urinary bladder cancer EJ-1 cell line

Zhenya Zhang, Peijuan Zhang, Michito Hamada, Satoru Takahashi, Guoqing Xing, Jiqiang Liu, Norio Sugiura
Pages: 1099-1103
Published online on: 01 November 2008

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Article

Reconstruction of the proximal humerus after extensive extraarticular resection for osteosarcoma: A report of two cases with clavicula pro humero reconstruction

Yoshihiro Nishida, Satoshi Tsukushi, Yoshihisa Yamada, Yuzuru Kamei, Kazuhiro Toriyama, Naoki Ishiguro
Pages: 1105-1109
Published online on: 01 November 2008

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Article

Potential role of dendritic cell vaccination with MAGE peptides in gastrointestinal carcinomas

Fumiaki Tanaka, Naotsugu Haraguchi, Kenji Isikawa, Hiroshi Inoue, Masaki Mori
Pages: 1111-1116
Published online on: 01 November 2008

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Article

Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis

Kenji Tsuboi, Yasuhiro Kodera, Hayao Nakanishi, Seiji Ito, Yoshinari Mochizuki, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yoshitaka Yamamura, Akimasa Nakao
Pages: 1117-1123
Published online on: 01 November 2008

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Article

Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer

Hidefumi Sasaki, Katsuhiro Okuda, Osamu Kawano, Haruhiro Yukiue, Motoki Yano, Yoshitaka Fujii
Pages: 1125-1130
Published online on: 01 November 2008

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Article

Positive immunohistochemical staining of γH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients

Kazuhiro Sentani, Naohide Oue, Naoya Sakamoto, Takashi Nishisaka, Toshiyuki Fukuhara, Hiroo Matsuura, Wataru Yasui
Pages: 1131-1136
Published online on: 01 November 2008

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Article

Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer

Yasuhiro Suga, Kuniharu Miyajima, Takefumi Oikawa, Junichi Maeda, Jitsuo Usuda, Naohiro Kajiwara, Tatsuo Ohira, Osamu Uchida, Masahiro Tsuboi, Takashi Hirano, Harubumi Kato, Norihiko Ikeda
Pages: 1137-1142
Published online on: 01 November 2008

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Article

Radiological imaging features of invasive micropapillary carcinoma of the breast and axillary lymph nodes

Kei Kubota, Yasuhiro Ogawa, Akihito Nishioka, Yoriko Murata, Satoshi Itoh, Norihiko Hamada, Kazuo Morio, Hironori Maeda, Yosuke Tanaka
Pages: 1143-1147
Published online on: 01 November 2008

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Article

Preclinical analysis of the antitumor efficacy of TS-1 using human uterine cervical cancer tumor xenografts

Nobutaka Nagai, Masaaki Komatsu, Mayu Yunokawa, Yuko Shiroyama, Eiji Hirata
Pages: 1149-1156
Published online on: 01 November 2008

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Article

Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors

Wei-Chen Tai, Seng-Kee Chuah, Jui-Wei Lin, Hong-Hwa Chen, Hsuan-Ying Huang, Chung-Mou Kuo, Li-Na Yi, Chuan-Mo Lee, Chi-Sin Changchien, Tsung-Hui Hu
Pages: 1157-1164
Published online on: 01 November 2008

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Article

Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer

Masashi Tsuruta, Hideki Nishibori, Hirotoshi Hasegawa, Yoshiyuki Ishii, Takashi Endo, Tetsuro Kubota, Masaki Kitajima, Yuko Kitagawa
Pages: 1165-1172
Published online on: 01 November 2008

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Article

Maintenance immunotherapy in metastatic breast cancer

Francesco Recchia, Gigliola Sica, Giampiero Candeloro, Stefano Necozione, Roberta Bisegna, Massimo Bratta, Silvio Rea
Pages: 1173-1179
Published online on: 01 November 2008

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Article

The C1772T genetic polymorphism in human HIF-1α gene associates with expression of HIF-1α protein in breast cancer

Hye Ok Kim, Yong Hwa Jo, Juhie Lee, Sang Sook Lee, Kyung-Sik Yoon
Pages: 1181-1187
Published online on: 01 November 2008

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Article

Comparison between intravenous and oral postoperative adjuvant immunochemotherapy in patients with stage II colorectal cancer

Isao Ito, Masaya Mukai, Hiromi Ninomiya, Kyoko Kishima, Kazutoshi Tsuchiya, Takayuki Tajima, Yasuhisa Oida, Masato Nakamura, Hiroyasu Makuuchi
Pages: 1189-1194
Published online on: 01 November 2008

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Article

Microsatellite analysis of serum DNA in patients with oral squamous cell carcinoma

Yoshidou Kakimoto, Nobuharu Yamamoto, Takahiko Shibahara
Pages: 1195-1200
Published online on: 01 November 2008

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Article

Neurotrophins and their receptors in human lingual tonsil: an immunohistochemical analysis

Marco Artico, Elena Bronzetti, Laura M. Felici, Valentina Alicino, Brunella Ionta, Benedetto Bronzetti, Giuseppe Magliulo, Claudia Grande, Loris Zamai, Guido Pasquantonio, Marco De Vincentiis
Pages: 1201-1206
Published online on: 01 November 2008

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Article

Effects of combination treatment of bortezomib and dexamethasone in SCCHN cell lines depend on tumor cell specificity

Jens Wagenblast, Mehran Baghi, Christoph Arnoldner, Sotirios Bisdas, Wolfgang Gstöttner, Angelika May, Rainald Knecht, Markus Hambek
Pages: 1207-1211
Published online on: 01 November 2008

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Article

Interleukin 1β-511T gene (IL1β) polymorphism is correlated with gastric cancer in the Caucasian population: Results from a meta-analysis

Bruno Vincenzi, Giuseppe Patti, Sara Galluzzo, Francesco Pantano, Olga Venditti, Daniele Santini, Annamaria Ruzzo, Gaia Schiavon, Michele Caraglia, Monica Marra, Francesco Graziano, Giuseppe Tonini
Pages: 1213-1220
Published online on: 01 November 2008

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Article

Endometrial adenocarcinoma: An analysis of treatment and outcome

Louise M. Byrd, Richard Swindell, Daniel Webber-Rookes, R. Hannon, Robin D. Hunter, Jac Livsey, Susan E. Davidson
Pages: 1221-1228
Published online on: 01 November 2008

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Article

Adenovirus-mediated expression of spermidine/spermine N1-acetyltransferase gene induces S-phase arrest in human colorectal cancer cells

Hui Sun, Bin Liu, Wei Wang, Guang-Shui Jiang, Wei Li, Ya-Pei Yang, Chun-Xiao Xu, Yun-Fei Yan, Xian-Xi Liu
Pages: 1229-1235
Published online on: 01 November 2008

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Article

Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells

Talin Haritunians, Saskia Gueller, James O'Kelly, Robert Ilaria, H. Phillip Koeffler
Pages: 1237-1242
Published online on: 01 November 2008

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Article

Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy

Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu, Mingxiong Guo, Wenxin Li
Pages: 1243-1248
Published online on: 01 November 2008

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Article

The histone-deacetylase inhibitor MS-275 and the CDK-inhibitor CYC-202 promote anti-tumor effects in hepatoma cell lines

Susanne Gahr, Gisela Peter, Thadäus Till Wissniowski, Eckhart G. Hahn, Christoph Herold, Matthias Ocker
Pages: 1249-1256
Published online on: 01 November 2008

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Article

Methylation-associated silencing of SFRP1 in renal cell carcinoma

Yasuo Awakura, Eijiro Nakamura, Noriyuki Ito, Toshiyuki Kamoto, Osamu Ogawa
Pages: 1257-1263
Published online on: 01 November 2008

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Article

The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas

Kentaro Kimura, Shinichi Toyooka, Kazunori Tsukuda, Hiromasa Yamamoto, Hiroshi Suehisa, Junichi Soh, Hiroki Otani, Takafumi Kubo, Keisuke Aoe, Nobukazu Fujimoto, Takumi Kishimoto, Yoshifumi Sano, Harvery I. Pass, Hiroshi Date
Pages: 1265-1268
Published online on: 01 November 2008

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Article

Impact of oxaliplatin and a novel DACH-platinum complex in the gene expression of HCT116 colon cancer cells

Siu-Kwong Pang, Chun-Wing Yu, Huaji Guan, Steve C.F. Au-Yeung, Yee-Ping Ho
Pages: 1269-1276
Published online on: 01 November 2008

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Article

In vitro photodynamic therapy in pediatric epithelial liver tumors promoted by hypericin

Guido Seitz, Renita Krause, Jörg Fuchs, Heike Heitmann, Sorin Armeanu, Peter Ruck, Steven W. Warmann
Pages: 1277-1282
Published online on: 01 November 2008

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Article

Proteasome inhibition by bortezomib does not translate into efficacy on two malignant glioma xenografts

Marianne Labussiere, Sophie Pinel, Suzanne Delfortrie, François Plenat, Pascal Chastagner
Pages: 1283-1287
Published online on: 01 November 2008

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Article

Inhibition of estrogen receptor positive and negative breast cancer cell lines with a growth hormone-releasing hormone antagonist

Stephan Seitz, Florian Hohla, Andrew V. Schally, Angelika Moder, Joerg B. Engel, Felicitas Horn, Josef Varga, Marta Zarandi, Olaf Ortmann, Frank Köster, Stefan Buchholz
Pages: 1289-1294
Published online on: 01 November 2008

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Journal Cover
March-2026 Volume 55 Issue 3

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Journal Metrics

Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Collaborative breakthroughs in precision diagnosis and treatment of nasopharyngeal cancer: Biomarker‑driven screening and endoscopic minimally invasive surgery reshape the new paradigm of early intervention (Review)

E Jin, Wang Lin, Xiandong Zeng
Article Number: 53
Published online on: 23 January 2026

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Review Open Access

Key immune cells in the tumor immune microenvironment of colorectal cancer: Roles and research advances (Review)

Ming Qiu, Chongyuan Lan, Minglin Lin, Hui Ma
Article Number: 52
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy

Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui
Article Number: 51
Published online on: 21 January 2026

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Review Open Access

Epigenetic mechanisms and therapeutic advances in diffuse midline glioma (Review)

Wenbo Wu, Wenlin Chen, Wenbin Ma, Yu Wang
Article Number: 50
Published online on: 20 January 2026

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Review Open Access

Recapitulating lung cancer metastasis in vitro: Advances in organoid models and challenges in clinical translation (Review)

Jian Jiang, Guomin Dong, Zhiyun Zhang, Xiaoyuan Lei, Fanshu Huang, Suoni Li, Jiequn Ma, Jie Bai, Qian Ge, Hui Wei, Zheng Zhao
Article Number: 49
Published online on: 20 January 2026

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Article Open Access

GPR176 enhances the epithelial‑mesenchymal transition in gastric cancer cells by activating the PI3K/AKT/mTOR signaling pathway

Guangchuan Mu, Kaiyan Li, Chaozhen Hu, Jintao Cai, Huichao Ruan, Guanyu Zhu, Dang Liu
Article Number: 48
Published online on: 19 January 2026

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Article Open Access

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation

Chenning Zhang, Yu Jiang, Jiahui Liu, Wenyu Zhang, Jie Qi, Qing Wen, Hengli Zhao
Article Number: 47
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] Prognostic significance of miR‑218 in human hepatocellular carcinoma and its role in cell growth

Kangsheng Tu, Chao Li, Xin Zheng, Wei Yang, Yingmin Yao, Qingguang Liu
Article Number: 46
Published online on: 19 January 2026

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Review Open Access

Tumor microenvironment in bone sarcomas: Implications for immunotherapy and emerging therapeutic vulnerabilities (Review)

Wentao Li, Lijun Lv, Yibin Jin, Xin Yuan
Article Number: 45
Published online on: 16 January 2026

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Review Open Access

Immunotherapy after EGFR‑TKI treatment in advanced non‑small cell lung cancer: Current status and future perspectives (Review)

Huiyuan Ma, Longhui Li, Conghan Jiao, Yanyan Cheng, Jiayu He, Chen Jiang, Qian Tong, Dan Yi, Ying Zhang
Article Number: 44
Published online on: 16 January 2026

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Correction Open Access

[Corrigendum] Triptolide inhibits JAK2/STAT3 signaling and induces lethal autophagy through ROS generation in cisplatin‑resistant SKOV3/DDP ovarian cancer cells

Yanying Zhong, Fuyin Le, Jiao Cheng, Chen Luo, Xiali Zhang, Xingwu Wu, Fang Xu, Qi Zuo, Buzhen Tan
Article Number: 43
Published online on: 13 January 2026

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Review Open Access

Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review)

Miriam Monteiro Alvares‑Vilela, Franciele Schlemmer, Sabrina Simplício de Araújo Romero Ferrari, Mary-Ann Elvina Xavier, Ricardo Titze‑de‑Almeida
Article Number: 42
Published online on: 14 January 2026

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Article Open Access

CDK1 depletion suppresses glioma malignancy through cell cycle pathway regulation: Mechanistic insights from functional and molecular profiling

Yu Wang, Huandi Zhou, Xuetao Han, Dongdong Zhang, Liubing Hou, Haonan Li, Tianyi Fan, Sijie Li, Xiaoying Xue
Article Number: 41
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] Downregulated microRNA‑200a promotes EMT and tumor growth through the Wnt/β‑catenin pathway by targeting the E‑cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma

Ningning Cong, Ping Du, Anling Zhang, Fajuan Shen, Juan Su, Peiyu Pu, Tao Wang, Jie Zjang, Chunsheng Kang, Qingyu Zhang
Article Number: 40
Published online on: 12 January 2026

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Review Open Access

Advances in targeting KRAS mutations: A promising approach for the treatment of non‑small cell lung cancer (Review)

Upesh Sharma, Jincheng Song, Hemraj Kandu, Yue Zhu, Zhaoxia Dai
Article Number: 39
Published online on: 08 January 2026

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Correction Open Access

[Corrigendum] CXCR6 predicts poor prognosis in gastric cancer and promotes tumor metastasis through epithelial-mesenchymal transition

Jie-Jie Jin, Fa-Xiang Dai, Zi-Wen Long, Hong Cai, Xiao-Wen Liu, Ye Zhou, Qi Hong, Qiong-Zhu Dong, Ya-Nong Wang, Hua Huang
Article Number: 38
Published online on: 05 January 2026

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April-2026 Volume 55 Issue 4

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Impact Factor: 3.9

CiteScore: 8.3

CiteScore Rank: Q1: #73/415 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

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