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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 20 Issue 5

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Article

Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression

  • Authors:
    • Bai-Li Chen
    • Jun Yu
    • Zhi-Rong Zeng
    • Wai-Kit Chu
    • Christine Y.P. Wong
    • Yuen-Yee Cheng
    • Joseph J.Y. Sung
    • Pin-Jin Hu
    • Wai K. Leung

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China
  • Pages: 1093-1097
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000114
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Abstract

Our previous study demonstrated that PPARγ ligand rosiglitazone prevents gastric carcinogenesis in rats induced by chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In this study, we attempted to identify novel anti-cancer mechanisms of rosiglitazone. By examining the gene expression profiles of MNNG-induced and rosiglitazone-treated gastric cancer with Uniset Rat I Bioarray microarray, we identified a gene that showed prominent responses in the rosiglitazone-treated group. The hypertension-related, calcium-regulated gene (HCaRG) was significantly up-regulated in rat gastric carcinoma of the rosiglitazone-treated group when compared with the MNNG group. We further examined HCaRG expression in human gastric cancer and found that the expression of HCaRG was down-regulated in human gastric cancerous tissue. Rosiglitazone markedly induced the expression of HCaRG in the AGS cell line. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Yu J, Zeng Z, Chu W, Wong CY, Cheng Y, Sung JJ, Hu P and Leung WK: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncol Rep 20: 1093-1097, 2008.
APA
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C.Y., Cheng, Y. ... Leung, W.K. (2008). Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncology Reports, 20, 1093-1097. https://doi.org/10.3892/or_00000114
MLA
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C. Y., Cheng, Y., Sung, J. J., Hu, P., Leung, W. K."Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression". Oncology Reports 20.5 (2008): 1093-1097.
Chicago
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C. Y., Cheng, Y., Sung, J. J., Hu, P., Leung, W. K."Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression". Oncology Reports 20, no. 5 (2008): 1093-1097. https://doi.org/10.3892/or_00000114
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Yu J, Zeng Z, Chu W, Wong CY, Cheng Y, Sung JJ, Hu P and Leung WK: Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncol Rep 20: 1093-1097, 2008.
APA
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C.Y., Cheng, Y. ... Leung, W.K. (2008). Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. Oncology Reports, 20, 1093-1097. https://doi.org/10.3892/or_00000114
MLA
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C. Y., Cheng, Y., Sung, J. J., Hu, P., Leung, W. K."Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression". Oncology Reports 20.5 (2008): 1093-1097.
Chicago
Chen, B., Yu, J., Zeng, Z., Chu, W., Wong, C. Y., Cheng, Y., Sung, J. J., Hu, P., Leung, W. K."Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression". Oncology Reports 20, no. 5 (2008): 1093-1097. https://doi.org/10.3892/or_00000114
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