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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 20 Issue 5

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Article

Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer

  • Authors:
    • Hidefumi Sasaki
    • Katsuhiro Okuda
    • Osamu Kawano
    • Haruhiro Yukiue
    • Motoki Yano
    • Yoshitaka Fujii

  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Nagoya City University Medical School, Nagoya 467-8601, Japan. hisasaki @med.nagoya-cu.ac.jp
  • Pages: 1125-1130
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000119
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Abstract

We investigated the FGFR4 mutation status at the kinase domain and FGFR4 single nucleotide polymorphism (SNP) at codon 388 in surgically treated non-small cell lung cancer (NSCLC) cases. The presence or absence of FGFR4 mutations of kinase domains was analyzed by direct sequences (n=147), and the presence of FGFR4 Arg388 allele was analyzed by genotyping assay using LightCycler hybridization probes (n=387). FGFR4 mutations were not present in our lung cancer patients. In 61.8% of patients, homo- or heterozygous Arg388 allele was present. No correlation existed between the FGFR4 genotype and clinicopathological features such as gender, smoking status and pathological subtypes. EGFR mutation status was not correlated with the FGFR4 genotype of lung cancers. In node-negative patients, the FGFR4 genotype was not correlated with disease outcome, while in the node-positive patients FGFR4 Arg388 was significantly associated with worse survival. This association was not attributed to patient response to adjuvant chemotherapy. Therefore, the role of FGFR4 polymorphism is a prognostic marker for advanced NSCLC in Japanese patients.

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki H, Okuda K, Kawano O, Yukiue H, Yano M and Fujii Y: Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. Oncol Rep 20: 1125-1130, 2008.
APA
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., & Fujii, Y. (2008). Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. Oncology Reports, 20, 1125-1130. https://doi.org/10.3892/or_00000119
MLA
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., Fujii, Y."Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer". Oncology Reports 20.5 (2008): 1125-1130.
Chicago
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., Fujii, Y."Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer". Oncology Reports 20, no. 5 (2008): 1125-1130. https://doi.org/10.3892/or_00000119
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki H, Okuda K, Kawano O, Yukiue H, Yano M and Fujii Y: Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. Oncol Rep 20: 1125-1130, 2008.
APA
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., & Fujii, Y. (2008). Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. Oncology Reports, 20, 1125-1130. https://doi.org/10.3892/or_00000119
MLA
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., Fujii, Y."Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer". Oncology Reports 20.5 (2008): 1125-1130.
Chicago
Sasaki, H., Okuda, K., Kawano, O., Yukiue, H., Yano, M., Fujii, Y."Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer". Oncology Reports 20, no. 5 (2008): 1125-1130. https://doi.org/10.3892/or_00000119
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