Positive immunohistochemical staining of γH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients

Sentani,Kazuhiro; Oue,Naohide; Sakamoto,Naoya; Nishisaka,Takashi; Fukuhara,Toshiyuki; Matsuura,Hiroo; Yasui,Wataru

doi:10.3892/or_00000120

November 2008 Volume 20 Issue 5

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November 2008 Volume 20 Issue 5

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Article

Positive immunohistochemical staining of γH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients

Authors:
- Kazuhiro Sentani
- Naohide Oue
- Naoya Sakamoto
- Takashi Nishisaka
- Toshiyuki Fukuhara
- Hiroo Matsuura
- Wataru Yasui
View Affiliations / Copyright

Affiliations: Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551, Japan
Pages: 1131-1136
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Published online on: November 1, 2008

https://doi.org/10.3892/or_00000120
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Abstract

To elucidate the mechanism of radiation-induced cancers, molecular analysis of cancers in atomic bomb (A-bomb) exposure is important. DNA double-strand breaks (DSBs) are thought to be caused by the deleterious effects of ionizing radiation, and γH2AX (serine 139 phosphorylated form of histone H2AX) is reported to be a significant marker for DSBs. In the present study, we performed immunohistochemical analysis of γH2AX in gastric cancers (GCs) from 66 exposed and 47 non-exposed patients who developed GC after the bombing. Of the 47 GCs from non-exposed patients, 6 (13%) cases showed nuclear positive staining for γH2AX, whereas of the 66 GCs from exposed patients, 20 (30%) cases were positive (P=0.0405). However, among stage I GC, there was no significant difference in γH2AX expression frequency between exposed patients and non-exposed patients. Among exposed patients, stage II-IV cases were more frequently positive for γH2AX than stage I cases (P=0.0197). Among GCs from non-exposed patients, γH2AX staining showed no significant association with Lauren's classification, depth of invasion, lymph node metastasis or TNM stage. These results suggest that the characteristics of tumor cells differ between GCs from exposed and non-exposed patients. DSBs may be involved in progression of GC in exposed patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Positive immunohistochemical staining of γH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients

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Abstract

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