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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2008 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells

  • Authors:
    • Talin Haritunians
    • Saskia Gueller
    • James O'Kelly
    • Robert Ilaria
    • H. Phillip Koeffler

  • View Affiliations / Copyright

    Affiliations: Division of Hematology/Oncology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA 90048, USA
  • Pages: 1237-1242
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/or_00000135
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Abstract

LY573636-sodium is a promising anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. Moreover, studies have shown that the compound is selectively toxic towards tumor cells over their normal counterparts. This targeted effect makes LY573636 a candidate for combined therapy regimens in patients with advanced or resistant cancers. We studied for the first time, the anti-tumor properties of LY573636 against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines. Cells were treated with the compound in vitro and its effect on cell proliferation, apoptosis and differentiation was determined. The cell lines underwent growth arrest in response to treatment with LY573636 in a dose-dependent manner. This antiproliferative activity was associated with the induction of apoptosis, loss of mitochondrial membrane potential and induction of reactive oxygen species. Furthermore, we showed that LY573636 was able to induce granulocytic/monocytic differentiation of HL60 and U937 cells. LY573636, as shown before in solid tumors, is effective in hematopoietic cell lines as well. These data suggest the use of LY573636 alone or in combination with conventional chemotherapeutic regimens in hematopoietic malignancies.

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Copy and paste a formatted citation
Spandidos Publications style
Haritunians T, Gueller S, O'Kelly J, Ilaria R and Koeffler HP: Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells. Oncol Rep 20: 1237-1242, 2008.
APA
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., & Koeffler, H.P. (2008). Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells. Oncology Reports, 20, 1237-1242. https://doi.org/10.3892/or_00000135
MLA
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., Koeffler, H. P."Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells". Oncology Reports 20.5 (2008): 1237-1242.
Chicago
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., Koeffler, H. P."Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells". Oncology Reports 20, no. 5 (2008): 1237-1242. https://doi.org/10.3892/or_00000135
Copy and paste a formatted citation
x
Spandidos Publications style
Haritunians T, Gueller S, O'Kelly J, Ilaria R and Koeffler HP: Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells. Oncol Rep 20: 1237-1242, 2008.
APA
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., & Koeffler, H.P. (2008). Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells. Oncology Reports, 20, 1237-1242. https://doi.org/10.3892/or_00000135
MLA
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., Koeffler, H. P."Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells". Oncology Reports 20.5 (2008): 1237-1242.
Chicago
Haritunians, T., Gueller, S., O'Kelly, J., Ilaria, R., Koeffler, H. P."Novel acyl sulfonamide LY573636-sodium: Effect on hematopoietic malignant cells". Oncology Reports 20, no. 5 (2008): 1237-1242. https://doi.org/10.3892/or_00000135
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