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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2008 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 20 Issue 6

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Article

Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma

  • Authors:
    • Yasushi Saga
    • Michitaka Ohwada
    • Mitsuaki Suzuki
    • Ryo Konno
    • Junzo Kigawa
    • Shuichi Ueno
    • Hiroyuki Mano

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi 329-0498, Japan. saga@jichi.ac.jp
  • Pages: 1299-1303
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/or_00000144
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Abstract

Ovarian clear cell adenocarcinoma has low sensitivity to platinum drugs. The molecular-biological mechanism of the low sensitivity has not been clarified. The objective of this study was to identify candidate genes associated with low sensitivity of clear cell adenocarcinoma to platinum drugs. Exhaustive gene profiling of 4 ovarian clear cell adenocarcinoma cell lines, KK, OVMANA, OVSAYO, and RMG-1 and 4 ovarian serous adenocarcinoma cell lines, KF, HRA, SHIN-3 and KOC-2S was performed by DNA microarray. Obtained candidate genes were suppressed by RNA interference and changes in the cisplatin sensitivity of clear cell adenocarcinoma cells were observed. Six genes including the glutathione peroxidase 3 (GPX3) gene were identified to be highly expressed in clear cell adenocarcinoma by DNA microarray analysis. GPX3 suppression by RNA interference increased cisplatin sensitivity 3.3-4.2-fold in 3 of the 4 clear cell adenocarcinoma cell lines. GPX3 was identified to be a gene highly expressed in clear cell adenocarcinoma. Since GPX3 suppression increased the cisplatin sensitivity of clear cell adenocarcinoma cells, GPX3 may be a candidate gene associated with the low cisplatin sensitivity of clear cell adenocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S and Mano H: Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep 20: 1299-1303, 2008.
APA
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., & Mano, H. (2008). Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncology Reports, 20, 1299-1303. https://doi.org/10.3892/or_00000144
MLA
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., Mano, H."Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". Oncology Reports 20.6 (2008): 1299-1303.
Chicago
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., Mano, H."Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". Oncology Reports 20, no. 6 (2008): 1299-1303. https://doi.org/10.3892/or_00000144
Copy and paste a formatted citation
x
Spandidos Publications style
Saga Y, Ohwada M, Suzuki M, Konno R, Kigawa J, Ueno S and Mano H: Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncol Rep 20: 1299-1303, 2008.
APA
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., & Mano, H. (2008). Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma. Oncology Reports, 20, 1299-1303. https://doi.org/10.3892/or_00000144
MLA
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., Mano, H."Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". Oncology Reports 20.6 (2008): 1299-1303.
Chicago
Saga, Y., Ohwada, M., Suzuki, M., Konno, R., Kigawa, J., Ueno, S., Mano, H."Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". Oncology Reports 20, no. 6 (2008): 1299-1303. https://doi.org/10.3892/or_00000144
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