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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2008 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 20 Issue 6

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Article

Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells

  • Authors:
    • Zhongsheng Xia
    • Zhaohua Zhu
    • Liyong Zhang
    • Crista Royal
    • Zhongmin Liu
    • Qikui Chen
    • Bao-Ling Adam

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, P.R. China. xiazhsh@hotmail.com
  • Pages: 1433-1439
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/or_00000163
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Abstract

No control cell line was available for previous RNA interference studies on reversal of multidrug resistance (MDR) in colon cancer cells. Here, human COLO 320DM, with HT-29 as the control, colon cancer cell lines were used to investigate the reversal of MDR1/P-gp-dependent MDR by siRNA (#4123 and #4029 MDR1 siRNAs) targeting to MDR1 mRNA. Both siRNAs inhibited expression of MDR1 and P-gp in COLO 320DM. The minimum inhibition concentrations were 5 nmol/l of #4123 and 25 nmol/l of #4029. #4123 MDR1 siRNA took effect in 4, 5 and 6 days at doses of 5, 25 and 100 nmol/l, respectively. Increased cytotoxicity of the antitumor drugs adriamycin and vincristine with increased intracellular adriamycin accumulation accompanied inhibition of MDR1 mRNA and P-gp expression. No such effects were found in the HT-29 control. MDR1 siRNAs specifically reversed the MDR of colon cancer cells demonstrating a possible new approach for treating MDR1/P-gp-dependent multidrug resistance.

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Copy and paste a formatted citation
Spandidos Publications style
Xia Z, Zhu Z, Zhang L, Royal C, Liu Z, Chen Q and Adam B: Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. Oncol Rep 20: 1433-1439, 2008.
APA
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., & Adam, B. (2008). Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. Oncology Reports, 20, 1433-1439. https://doi.org/10.3892/or_00000163
MLA
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., Adam, B."Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells". Oncology Reports 20.6 (2008): 1433-1439.
Chicago
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., Adam, B."Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells". Oncology Reports 20, no. 6 (2008): 1433-1439. https://doi.org/10.3892/or_00000163
Copy and paste a formatted citation
x
Spandidos Publications style
Xia Z, Zhu Z, Zhang L, Royal C, Liu Z, Chen Q and Adam B: Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. Oncol Rep 20: 1433-1439, 2008.
APA
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., & Adam, B. (2008). Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells. Oncology Reports, 20, 1433-1439. https://doi.org/10.3892/or_00000163
MLA
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., Adam, B."Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells". Oncology Reports 20.6 (2008): 1433-1439.
Chicago
Xia, Z., Zhu, Z., Zhang, L., Royal, C., Liu, Z., Chen, Q., Adam, B."Specific reversal of MDR1/P-gp-dependent multidrug resistance by RNA interference in colon cancer cells". Oncology Reports 20, no. 6 (2008): 1433-1439. https://doi.org/10.3892/or_00000163
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