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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2008 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 20 Issue 6

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Article

Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma

  • Authors:
    • Lai-Ping Zhong
    • Xiao Yang
    • Lei Zhang
    • Kui-Jie Wei
    • Hong-Ya Pan
    • Xiao-Jian Zhou
    • Jiang Li
    • Wan-Tao Chen
    • Zhi-Yuan Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, P.R. China
  • Pages: 1441-1447
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/or_00000164
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Abstract

Previously, we established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC), including a human immortalized oral epithelial cell (HIOEC) line and its derived cancerous HB96 cell line. Further cDNA microarray analysis showed a significant up-regulated gene, insulin-like growth factor binding protein 3 (IGFBP3), accompanying with in vitro cancerization from HIOEC to HB96. In order to investigate IGFBP3 up-regulation and its potential usefulness as a molecular marker in OSCC, we detected the IGFBP3 expression with a panel of OSCC lines, and clinical samples of cancerous tissues and paired adjacent non-malignant epithelia from primary OSCC patients. Western blotting and real-time PCR showed increased IGFBP3 mRNA level and protein expression in OSCC cell lines compared with HIOEC in vitro; immunohistochemistry and real-time PCR also showed increased IGFBP3 mRNA level and protein expression in cancerous tissues compared with adjacent non-malignant epithelia from OSCC patients. Positive correlations were found between the IGFBP3 protein-positive grade in cancerous tissue and the tumor size as well as lymph node metastasis, a larger tumor size and positive lymph node metastasis indicating a higher level of IGFBP3 protein-positive grade. Based on these results, IGFBP3 may be used as a positive biomarker for OSCC development and progression.

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Copy and paste a formatted citation
Spandidos Publications style
Zhong L, Yang X, Zhang L, Wei K, Pan H, Zhou X, Li J, Chen W and Zhang Z: Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma. Oncol Rep 20: 1441-1447, 2008.
APA
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X. ... Zhang, Z. (2008). Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma. Oncology Reports, 20, 1441-1447. https://doi.org/10.3892/or_00000164
MLA
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X., Li, J., Chen, W., Zhang, Z."Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma". Oncology Reports 20.6 (2008): 1441-1447.
Chicago
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X., Li, J., Chen, W., Zhang, Z."Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma". Oncology Reports 20, no. 6 (2008): 1441-1447. https://doi.org/10.3892/or_00000164
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong L, Yang X, Zhang L, Wei K, Pan H, Zhou X, Li J, Chen W and Zhang Z: Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma. Oncol Rep 20: 1441-1447, 2008.
APA
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X. ... Zhang, Z. (2008). Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma. Oncology Reports, 20, 1441-1447. https://doi.org/10.3892/or_00000164
MLA
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X., Li, J., Chen, W., Zhang, Z."Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma". Oncology Reports 20.6 (2008): 1441-1447.
Chicago
Zhong, L., Yang, X., Zhang, L., Wei, K., Pan, H., Zhou, X., Li, J., Chen, W., Zhang, Z."Overexpression of insulin-like growth factor binding protein 3 in oral squamous cell carcinoma". Oncology Reports 20, no. 6 (2008): 1441-1447. https://doi.org/10.3892/or_00000164
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