Soluble transforming growth factor β type II receptor attenuates TGF-β1 activity in human colorectal cancer LoVo cells

  • Authors:
    • Rui Zhou
    • Bin Xiong
    • Haibin Song
    • Shiquan Liu
    • Xinbo Wang
  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/or_00000165
  • Pages: 1449-1456
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Abstract

Several lines of evidence support an important role of TGF-β in the development of colorectal cancer, although the molecular consequences are largely unknown. Soluble transforming growth factor-β receptor type II (sTβRII) is a target of transforming growth factors-β (TGF-β) that plays an important role in regulation tumorigenesis, angiogenesis and metastasis of cancer. To elucidate whether overexpression of sTβRII could antagonize TGF-β in colon cancer cells, we constructed a plasmid that contains a cDNA encoding human extracellular region of TβRII and transfected this construction into LoVo cells. Surprisingly, in the absence of TGF-β1, the overexpression of sTβRII antagonized TGF-β-induced cell proliferation, invasion, motility and angiogenesis, and decreased expression of VEGF and MMP-9. Also, sTβRII inhibited TGF-β-induced apoptosis and improved the induction of antitumor immunity. Our data indicated that sTβRII attenuated the biological activities of TGF-β, suggesting that sTβRII may have a therapeutic benefit in colorectal cancer.

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December 2008
Volume 20 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhou R, Xiong B, Song H, Liu S and Wang X: Soluble transforming growth factor β type II receptor attenuates TGF-β1 activity in human colorectal cancer LoVo cells. Oncol Rep 20: 1449-1456, 2008.
APA
Zhou, R., Xiong, B., Song, H., Liu, S., & Wang, X. (2008). Soluble transforming growth factor β type II receptor attenuates TGF-β1 activity in human colorectal cancer LoVo cells. Oncology Reports, 20, 1449-1456. https://doi.org/10.3892/or_00000165
MLA
Zhou, R., Xiong, B., Song, H., Liu, S., Wang, X."Soluble transforming growth factor β type II receptor attenuates TGF-β1 activity in human colorectal cancer LoVo cells". Oncology Reports 20.6 (2008): 1449-1456.
Chicago
Zhou, R., Xiong, B., Song, H., Liu, S., Wang, X."Soluble transforming growth factor β type II receptor attenuates TGF-β1 activity in human colorectal cancer LoVo cells". Oncology Reports 20, no. 6 (2008): 1449-1456. https://doi.org/10.3892/or_00000165