A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas

  • Authors:
    • Takao Matsubara
    • Katsuyuki Kusuzaki
    • Akihiko Matsumine
    • Hiroaki Murata
    • Haruhiko Satonaka
    • Ken Shintani
    • Tomoki Nakamura
    • Hajime Hosoi
    • Tomoko Iehara
    • Toru Sugimoto
    • Atsumasa Uchida
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000193
  • Pages: 89-94
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Abstract

Rhabdomyosarcoma is a common malignant soft tissue that frequently involves bone and major neurovascular structures and resection of deep-seated rhabdomyosarcoma can cause severe dysfunction in the affected limbs. Based on the mouse osteosarcoma model, we developed a new surgical approach involving photodynamic surgery (PDS), photodynamic therapy (PDT) and radiodynamic therapy (RDT) using acridine orange (AO). Six rhabdomyosarcoma cases were treated using this new modality after confirming the effectiveness of AO-PDT on human rhabdomyosarcoma cell lines. All patients had almost normal limb function after surgery, with only one recurrence. Based on these results, AO-PDS, PDT and RDT can be used to preserve excellent limb function in patients with rhabdomyosarcoma involving major nerves and vessels or bones.

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January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Matsubara T, Kusuzaki K, Matsumine A, Murata H, Satonaka H, Shintani K, Nakamura T, Hosoi H, Iehara T, Sugimoto T, Sugimoto T, et al: A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas. Oncol Rep 21: 89-94, 2009
APA
Matsubara, T., Kusuzaki, K., Matsumine, A., Murata, H., Satonaka, H., Shintani, K. ... Uchida, A. (2009). A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas. Oncology Reports, 21, 89-94. https://doi.org/10.3892/or_00000193
MLA
Matsubara, T., Kusuzaki, K., Matsumine, A., Murata, H., Satonaka, H., Shintani, K., Nakamura, T., Hosoi, H., Iehara, T., Sugimoto, T., Uchida, A."A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas". Oncology Reports 21.1 (2009): 89-94.
Chicago
Matsubara, T., Kusuzaki, K., Matsumine, A., Murata, H., Satonaka, H., Shintani, K., Nakamura, T., Hosoi, H., Iehara, T., Sugimoto, T., Uchida, A."A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas". Oncology Reports 21, no. 1 (2009): 89-94. https://doi.org/10.3892/or_00000193