Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer

  • Authors:
    • Sung-Won Shin
    • Hyuk-Chan Kwon
    • Mee-Sook Rho
    • Hong-Jo Choi
    • Jong-Young Kwak
    • Joo-In Park
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000195
  • Pages: 101-106
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Abstract

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) plays an essential role in angiogenesis and development. A previous study showed that the expression of COUP-TFII enhanced invasiveness of human lung carcinoma cells. However, no published data are available concerning the biological and clinical significance of COUP-TFII expression in colorectal cancer. Thus, our objective was to explore the expression of COUP-TFII in colorectal cancer as well as its association with clinicopathological features, and to evaluate the role of COUP-TFII as a prognostic indicator in colorectal cancer. We investigated the presence of COUP-TFII in human colorectal cancer tissues and adjacent normal tissues from 95 primary colorectal cancer patients by immunohistochemistry. The correlation between the expression of COUP-TFII and clinicopathologic features was investigated. The 3-year disease-free survival (DFS) and overall survival (OS) of patients with tumors expressing different levels of COUP-TFII were evaluated by the Kaplan-Meier method. No significant correlation was found between COUP-TFII expression and age at surgery, gender, histopathologic differentiation, vessel invasion, carcinoembryonic antigen (CEA), or nodal involvement. However, survival analysis showed that the COUP-TFII-positive group had a significantly better OS compared to COUP-TFII-negative group (80.4% vs. 57.7%, P=0.0491). Based on our results, COUP-TFII may represent a biomarker for good prognosis in colorectal cancer.

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January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shin S, Kwon H, Rho M, Choi H, Kwak J and Park J: Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer. Oncol Rep 21: 101-106, 2009
APA
Shin, S., Kwon, H., Rho, M., Choi, H., Kwak, J., & Park, J. (2009). Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer. Oncology Reports, 21, 101-106. https://doi.org/10.3892/or_00000195
MLA
Shin, S., Kwon, H., Rho, M., Choi, H., Kwak, J., Park, J."Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer". Oncology Reports 21.1 (2009): 101-106.
Chicago
Shin, S., Kwon, H., Rho, M., Choi, H., Kwak, J., Park, J."Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer". Oncology Reports 21, no. 1 (2009): 101-106. https://doi.org/10.3892/or_00000195