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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2009 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2009 Volume 21 Issue 1

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Article

Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells

  • Authors:
    • Xiao-Ming Bai
    • Wei Zhang
    • Ning-Bo Liu
    • Hui Jiang
    • Ke-Xin Lou
    • Tao Peng
    • Juan Ma
    • Li Zhang
    • Hai Zhang
    • Jing Leng

  • View Affiliations / Copyright

    Affiliations: Laboratory of Reproductive Medicine, Cancer Center, Department of Pathology, Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 129-136
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/or_00000199
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Abstract

Prostaglandin E2 has been implicated in cell growth and metastasis in many types of cancers. However, the effects of PGE2 and its mechanism on cell adhesion, migration, and invasion have not been clarified yet. In this study, we found PGE2 treatment significantly increased the cell adhesion, migration, and invasion in hepatocellular carcinoma (HCC) cells. In addition, the effects of PGE2 were found to be associated with focal adhesion kinase (FAK). PGE2 treatment increased the phosphorylation and synthesis of FAK in a dose-dependent manner. RNA interference targeting FAK suppressed PGE2-mediated cell adhesion and migration. Furthermore, the downstream proteins of FAK, paxillin and Erk2, were also activated by PGE2. PGE2 treatment increased the phosphorylation and synthesis of paxillin in a dose-dependent manner. PGE2 treatment also induced the phosphorylation of Erk2. PD98059, the specific inhibitor of MEK, suppressed PGE2-mediated cell adhesion and migration. However, it had no effect on PGE2-induced activation and synthesis of FAK. These results demonstrated that PGE2 greatly induced HCC cell adhesion, migration, and invasion by activating FAK/paxillin/Erk pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Bai X, Zhang W, Liu N, Jiang H, Lou K, Peng T, Ma J, Zhang L, Zhang H, Leng J, Leng J, et al: Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncol Rep 21: 129-136, 2009.
APA
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T. ... Leng, J. (2009). Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncology Reports, 21, 129-136. https://doi.org/10.3892/or_00000199
MLA
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T., Ma, J., Zhang, L., Zhang, H., Leng, J."Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells". Oncology Reports 21.1 (2009): 129-136.
Chicago
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T., Ma, J., Zhang, L., Zhang, H., Leng, J."Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells". Oncology Reports 21, no. 1 (2009): 129-136. https://doi.org/10.3892/or_00000199
Copy and paste a formatted citation
x
Spandidos Publications style
Bai X, Zhang W, Liu N, Jiang H, Lou K, Peng T, Ma J, Zhang L, Zhang H, Leng J, Leng J, et al: Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncol Rep 21: 129-136, 2009.
APA
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T. ... Leng, J. (2009). Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncology Reports, 21, 129-136. https://doi.org/10.3892/or_00000199
MLA
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T., Ma, J., Zhang, L., Zhang, H., Leng, J."Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells". Oncology Reports 21.1 (2009): 129-136.
Chicago
Bai, X., Zhang, W., Liu, N., Jiang, H., Lou, K., Peng, T., Ma, J., Zhang, L., Zhang, H., Leng, J."Focal adhesion kinase: Important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells". Oncology Reports 21, no. 1 (2009): 129-136. https://doi.org/10.3892/or_00000199
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