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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2009 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma

  • Authors:
    • Kai Hu
    • Ye-Hua Gan
    • Sheng-Lin Li
    • Yan Gao
    • Deng-Cheng Wu
    • Cun-Yu Wang
    • Guang-Yan Yu

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China
  • Pages: 137-143
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/or_00000200
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Abstract

Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC). Although activation of extracellular signal-regulated kinase 1/2 (ERK1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear. We examined the expression of activated ERK1/2 in SACC-LM with high lung-metastatic rate and SACC-83 with low lung-metastatic rate, as well as in the tissues from lung-metastatic and non-metastatic groups of SACC patients. Western blot analysis indicated that SACC-LM exhibited higher expression of activated ERK1/2 than SACC-83. Similarly, immunohistochemistry showed that expression of activated ERK1/2 was detected in 73% (8/11) of the primary tissues from SACC patients with lung metastasis, while only 25% (3/12) of the primary tissues from SACC patients without lung metastasis (P<0.05). Furthermore, we examined the effects of U0126, a specific inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK), on migration and invasion in SACC-LM cells, showing U0126 not only inactivated ERK1/2, but also inhibited migration and invasion of SACC-LM. The present findings suggested that the elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hu K, Gan Y, Li S, Gao Y, Wu D, Wang C and Yu G: Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep 21: 137-143, 2009.
APA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., & Yu, G. (2009). Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncology Reports, 21, 137-143. https://doi.org/10.3892/or_00000200
MLA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21.1 (2009): 137-143.
Chicago
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21, no. 1 (2009): 137-143. https://doi.org/10.3892/or_00000200
Copy and paste a formatted citation
x
Spandidos Publications style
Hu K, Gan Y, Li S, Gao Y, Wu D, Wang C and Yu G: Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep 21: 137-143, 2009.
APA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., & Yu, G. (2009). Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncology Reports, 21, 137-143. https://doi.org/10.3892/or_00000200
MLA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21.1 (2009): 137-143.
Chicago
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21, no. 1 (2009): 137-143. https://doi.org/10.3892/or_00000200
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