Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma

  • Authors:
    • Kai Hu
    • Ye-Hua Gan
    • Sheng-Lin Li
    • Yan Gao
    • Deng-Cheng Wu
    • Cun-Yu Wang
    • Guang-Yan Yu
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000200
  • Pages: 137-143
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung metastasis is one of the important characteristics of salivary adenoid cystic carcinoma (SACC). Although activation of extracellular signal-regulated kinase 1/2 (ERK1/2) pathway may be associated with cancer progression in some malignant tumors, its roles in lung metastasis of SACC remains unclear. We examined the expression of activated ERK1/2 in SACC-LM with high lung-metastatic rate and SACC-83 with low lung-metastatic rate, as well as in the tissues from lung-metastatic and non-metastatic groups of SACC patients. Western blot analysis indicated that SACC-LM exhibited higher expression of activated ERK1/2 than SACC-83. Similarly, immunohistochemistry showed that expression of activated ERK1/2 was detected in 73% (8/11) of the primary tissues from SACC patients with lung metastasis, while only 25% (3/12) of the primary tissues from SACC patients without lung metastasis (P<0.05). Furthermore, we examined the effects of U0126, a specific inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK), on migration and invasion in SACC-LM cells, showing U0126 not only inactivated ERK1/2, but also inhibited migration and invasion of SACC-LM. The present findings suggested that the elevated expression of activated ERK1/2 may play a role in lung metastasis of salivary adenoid cystic carcinoma.

Related Articles

Journal Cover

January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hu K, Gan Y, Li S, Gao Y, Wu D, Wang C and Yu G: Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncol Rep 21: 137-143, 2009
APA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., & Yu, G. (2009). Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma. Oncology Reports, 21, 137-143. https://doi.org/10.3892/or_00000200
MLA
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21.1 (2009): 137-143.
Chicago
Hu, K., Gan, Y., Li, S., Gao, Y., Wu, D., Wang, C., Yu, G."Relationship of activated extracellular signal-regulated kinase 1/2 with lung metastasis in salivary adenoid cystic carcinoma". Oncology Reports 21, no. 1 (2009): 137-143. https://doi.org/10.3892/or_00000200