Mitochondrial ultrastructure-associated chemotherapy response in ovarian cancer

Saitou,Motoaki; Isonishi,Seiji; Hamada,Tomomi; Kiyokawa,Takako; Tachibana,Toshiaki; Ishikawa,Hiroshi; Yasuda,Makoto

doi:10.3892/or_00000208

January 2009 Volume 21 Issue 1

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January 2009 Volume 21 Issue 1

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Article

Mitochondrial ultrastructure-associated chemotherapy response in ovarian cancer

Authors:
- Motoaki Saitou
- Seiji Isonishi
- Tomomi Hamada
- Takako Kiyokawa
- Toshiaki Tachibana
- Hiroshi Ishikawa
- Makoto Yasuda
View Affiliations / Copyright

Affiliations: Department of Obstetrics/Gynecology, Jikei University School of Medicine, Tokyo 105, Japan
Pages: 199-204
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Published online on: January 1, 2009

https://doi.org/10.3892/or_00000208
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Abstract

We developed mitochondrial (MT) scoring system based on MT ultrastructural findings in association with response to chemotherapy in ovarian cancer (OC). Ultrathin sections of MT prepared from 28 OC patients before chemotherapy were examined by electron microscopy. Platinum-sensitive ovarian carcinoma cell line 2008 and its resistant variant C13 were used as control cells. Seven independent MT features including, diameter, pattern of cresta structure, electron density, distribution-density and -pattern, ratio of minimal/maximal diameter and MT architecture were examined and were assigned a score between 0 and 2. Twenty-eight cases were primary advanced OC, including 4 recurrent cases. Nine cases were chemosensitive while 19 were resistant. Univariate and multivariate analysis in each factor showed good correlation to chemosensitivity for 2 factors of electron density, distribution pattern. Total score of these 2 factors in 9 sensitive cells was 1.44±0.41 (M ± SE) and was 3.58±0.18 in 19 resistant cells (P<0.001). Receptor operative characteristics (ROC) analysis revealed that total ‘cut-off’ score was 3 point (P<0.05; AUC=0.84). In conclusion, this MT scoring system was excellently correlated to response regardless of histopathologic findings and this strongly suggests that the system is deemed to be of great value as biomarker for the chemosensitivity in OC.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Mitochondrial ultrastructure-associated chemotherapy response in ovarian cancer

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Abstract

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