Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1

  • Authors:
    • A. Stebel
    • C. Brachetti
    • M. Kunkel
    • M. Schmidt
    • G. Fritz
  • View Affiliations

  • Published online on: January 1, 2009     https://doi.org/10.3892/or_00000211
  • Pages: 217-222
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Abstract

In this study, we investigated the expression level of Ras-homologous (Rho) GTPases and the Rho guanine exchange factor (GEF) T-cell lymphoma invasion and metastasis 1 (Tiam1) in breast tumor specimens (n=106) by immunohistochemistry. Rho and Rho-GEF expression scores were compared to clinically established diagnostic and prognostic parameters. We found that RhoA and RhoB scores slightly increased with tumor grade, whereas the Rac1 score remained unaffected. The most significant effects were observed for the Rac1-specific GEF Tiam1. Tiam1 expression scores significantly decreased with the increase in tumor grade, tumor spreading and proliferation. Furthermore, Tiam1 expression was inversely related to the plasminogen activator inhibitor (PAI-1) and estrogen receptor (ER) expression but not the progesterone receptor (PR) and urokinase plasminogen activator (uPA). A low Tiam1 expression was associated with p53 positivity without being related to HER2/neu status. The data show that Tiam1 expression decreases with the progression of breast carcinomas and is inversely associated with several established breast tumor markers. Therefore, we suggest that Tiam1 counteracts the progression of breast carcinomas and is suitable as a novel breast tumor marker.

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January 2009
Volume 21 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stebel A, Brachetti C, Kunkel M, Schmidt M and Fritz G: Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1. Oncol Rep 21: 217-222, 2009
APA
Stebel, A., Brachetti, C., Kunkel, M., Schmidt, M., & Fritz, G. (2009). Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1. Oncology Reports, 21, 217-222. https://doi.org/10.3892/or_00000211
MLA
Stebel, A., Brachetti, C., Kunkel, M., Schmidt, M., Fritz, G."Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1". Oncology Reports 21.1 (2009): 217-222.
Chicago
Stebel, A., Brachetti, C., Kunkel, M., Schmidt, M., Fritz, G."Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1". Oncology Reports 21, no. 1 (2009): 217-222. https://doi.org/10.3892/or_00000211