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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2009 Volume 21 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article Open Access

Bidirectionality and transcriptional activity of the EWSR1 promoter region

  • Authors:
    • Emely Möller
    • Nils Mandahl
    • Mariola Iliszko
    • Fredrik Mertens
    • Ioannis Panagopoulos

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden. emely.moller@med.lu.se
  • Pages: 641-648
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/or_00000267
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Abstract

EWSR1 is involved in chimeric proteins which play crucial roles in the development of a variety of bone and soft tissue tumors. Many of the chimeric genes involving EWSR1 have been extensively studied, whereas less is known about the wild-type (wt) gene and its regulation. As the expression of the chimeric gene is driven by the EWSR1 promoter, it is of importance to study the mechanisms regulating wt EWSR1 expression. We estimated the transcriptional activity of the EWSR1 promoter through deletion fragments driving reporter gene expression. This assay identified the 100-bp region immediately downstream of the EWSR1 transcriptional start site (+1) and the downstream region from +100 to +300 as important regions for transcriptional regulation. We also found that EWSR1 and RHBDD3, a gene located directly upstream of EWSR1 that is likely to share regulatory elements with EWSR1, were co-expressed in the tissue panels, Ewing tumor biopsies and cell lines. Thus, our results show that the EWSR1 promoter functions in a bidirectional manner, thereby regulating also RHBDD3, and identifies specific regions that strongly influence promoter activity.

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Copy and paste a formatted citation
Spandidos Publications style
Möller E, Mandahl N, Iliszko M, Mertens F and Panagopoulos I: Bidirectionality and transcriptional activity of the EWSR1 promoter region. Oncol Rep 21: 641-648, 2009.
APA
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., & Panagopoulos, I. (2009). Bidirectionality and transcriptional activity of the EWSR1 promoter region. Oncology Reports, 21, 641-648. https://doi.org/10.3892/or_00000267
MLA
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., Panagopoulos, I."Bidirectionality and transcriptional activity of the EWSR1 promoter region". Oncology Reports 21.3 (2009): 641-648.
Chicago
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., Panagopoulos, I."Bidirectionality and transcriptional activity of the EWSR1 promoter region". Oncology Reports 21, no. 3 (2009): 641-648. https://doi.org/10.3892/or_00000267
Copy and paste a formatted citation
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Spandidos Publications style
Möller E, Mandahl N, Iliszko M, Mertens F and Panagopoulos I: Bidirectionality and transcriptional activity of the EWSR1 promoter region. Oncol Rep 21: 641-648, 2009.
APA
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., & Panagopoulos, I. (2009). Bidirectionality and transcriptional activity of the EWSR1 promoter region. Oncology Reports, 21, 641-648. https://doi.org/10.3892/or_00000267
MLA
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., Panagopoulos, I."Bidirectionality and transcriptional activity of the EWSR1 promoter region". Oncology Reports 21.3 (2009): 641-648.
Chicago
Möller, E., Mandahl, N., Iliszko, M., Mertens, F., Panagopoulos, I."Bidirectionality and transcriptional activity of the EWSR1 promoter region". Oncology Reports 21, no. 3 (2009): 641-648. https://doi.org/10.3892/or_00000267
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