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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2009 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2009 Volume 21 Issue 3

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Article

Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma

  • Authors:
    • Markus Hoffmann
    • David Scheunemann
    • Asita Fazel
    • Tibor Görögh
    • Tomas Kahn
    • Stefan Gottschlich

  • View Affiliations / Copyright

    Affiliations: Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Christian-Albrechts-Universität Kiel, D-24105 Kiel, Germany. mhoffmann@hno.uni-kiel.de
  • Pages: 809-814
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/or_00000288
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Abstract

The impact of a polymorphism of the wild-type human tumour suppressor gene p53(wt) on carcinogenesis is subject of controversy ever since a higher susceptibility of p53 to HPV-E6 mediated degradation when encoding for Arginine at codon 72 (p53Arg) was first reported. The issue remained unclear because various studies investigating this question for different tumour entities and different geographical regions demonstrated diverging results. In the present study, the HPV status and p53 genotype frequency of 42 head and neck cancers was analysed and compared to results reported in the recent literature. Applying PCR and cycle sequencing techniques, HPV DNA was demonstrated in 12/42 (29%) of the cases and the overall distribution of the p53 allele was: 64, 31 and 5% for p53Arg, p53Arg/Pro and p53Pro, respectively. There was no statistically significant association between HPV status and p53 genotype distribution. The results of our study and of the reviewed literature do not support a relevant role of the p53 polymorphism in head and neck carcinogenesis, either taken alone or in association with the HPV status.

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Copy and paste a formatted citation
Spandidos Publications style
Hoffmann M, Scheunemann D, Fazel A, Görögh T, Kahn T and Gottschlich S: Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncol Rep 21: 809-814, 2009.
APA
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., & Gottschlich, S. (2009). Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncology Reports, 21, 809-814. https://doi.org/10.3892/or_00000288
MLA
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., Gottschlich, S."Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma". Oncology Reports 21.3 (2009): 809-814.
Chicago
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., Gottschlich, S."Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma". Oncology Reports 21, no. 3 (2009): 809-814. https://doi.org/10.3892/or_00000288
Copy and paste a formatted citation
x
Spandidos Publications style
Hoffmann M, Scheunemann D, Fazel A, Görögh T, Kahn T and Gottschlich S: Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncol Rep 21: 809-814, 2009.
APA
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., & Gottschlich, S. (2009). Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncology Reports, 21, 809-814. https://doi.org/10.3892/or_00000288
MLA
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., Gottschlich, S."Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma". Oncology Reports 21.3 (2009): 809-814.
Chicago
Hoffmann, M., Scheunemann, D., Fazel, A., Görögh, T., Kahn, T., Gottschlich, S."Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma". Oncology Reports 21, no. 3 (2009): 809-814. https://doi.org/10.3892/or_00000288
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