Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma

  • Authors:
    • Takahiro Toyokawa
    • Masakazu Yashiro
    • Kosei Hirakawa
  • View Affiliations

  • Published online on: April 1, 2009     https://doi.org/10.3892/or_00000297
  • Pages: 875-880
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Keratinocyte growth factor (KGF) from gastric fibroblasts have been reported to stimulate proliferation of scirrhous gastric cancer cells with K-samII amplification in a paracrine manner. The aim of this study was to evaluate the clinical significance of the co-expression of K-sam and KGF in gastric carcinomas. A total of 136 primary gastric tumors were investigated by staining with antibodies against K-sam and KGF. K-sam expression on cancer cells and KGF expression on fibroblasts was estimated. The relationship between the K-sam and/or KGF expression and the clinicopathological characteristics were analyzed. K-sam expression was positive in 42 (31%) of 136 gastric carcinomas. K-sam expression was positively correlated with scirrhous cancer (p<0.001), diffuse type (p=0.031), invasion depth (p=0.018) and infiltration type (p<0.001). Prognosis of K-sam positive patients was significantly poorer than that of K-sam negative patients (p<0.001). The prognosis of patients with both K-sam and KGF positive tumors was significantly worse in comparison to either negative tumors (p<0.001). In 94 patients with a curative resection, a multivariate analysis revealed the co-expression of K-sam and KGF to be an independent prognostic factor (p=0.029). In conclusion, the co-expression of K-sam and KGF in gastric cancer might be a useful prognostic factor.

Related Articles

Journal Cover

April 2009
Volume 21 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Toyokawa T, Yashiro M and Hirakawa K: Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep 21: 875-880, 2009.
APA
Toyokawa, T., Yashiro, M., & Hirakawa, K. (2009). Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncology Reports, 21, 875-880. https://doi.org/10.3892/or_00000297
MLA
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21.4 (2009): 875-880.
Chicago
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21, no. 4 (2009): 875-880. https://doi.org/10.3892/or_00000297