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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2009 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma

  • Authors:
    • Takahiro Toyokawa
    • Masakazu Yashiro
    • Kosei Hirakawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
  • Pages: 875-880
    |
    Published online on: April 1, 2009
       https://doi.org/10.3892/or_00000297
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Abstract

Keratinocyte growth factor (KGF) from gastric fibroblasts have been reported to stimulate proliferation of scirrhous gastric cancer cells with K-samII amplification in a paracrine manner. The aim of this study was to evaluate the clinical significance of the co-expression of K-sam and KGF in gastric carcinomas. A total of 136 primary gastric tumors were investigated by staining with antibodies against K-sam and KGF. K-sam expression on cancer cells and KGF expression on fibroblasts was estimated. The relationship between the K-sam and/or KGF expression and the clinicopathological characteristics were analyzed. K-sam expression was positive in 42 (31%) of 136 gastric carcinomas. K-sam expression was positively correlated with scirrhous cancer (p<0.001), diffuse type (p=0.031), invasion depth (p=0.018) and infiltration type (p<0.001). Prognosis of K-sam positive patients was significantly poorer than that of K-sam negative patients (p<0.001). The prognosis of patients with both K-sam and KGF positive tumors was significantly worse in comparison to either negative tumors (p<0.001). In 94 patients with a curative resection, a multivariate analysis revealed the co-expression of K-sam and KGF to be an independent prognostic factor (p=0.029). In conclusion, the co-expression of K-sam and KGF in gastric cancer might be a useful prognostic factor.

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Copy and paste a formatted citation
Spandidos Publications style
Toyokawa T, Yashiro M and Hirakawa K: Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep 21: 875-880, 2009.
APA
Toyokawa, T., Yashiro, M., & Hirakawa, K. (2009). Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncology Reports, 21, 875-880. https://doi.org/10.3892/or_00000297
MLA
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21.4 (2009): 875-880.
Chicago
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21, no. 4 (2009): 875-880. https://doi.org/10.3892/or_00000297
Copy and paste a formatted citation
x
Spandidos Publications style
Toyokawa T, Yashiro M and Hirakawa K: Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep 21: 875-880, 2009.
APA
Toyokawa, T., Yashiro, M., & Hirakawa, K. (2009). Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncology Reports, 21, 875-880. https://doi.org/10.3892/or_00000297
MLA
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21.4 (2009): 875-880.
Chicago
Toyokawa, T., Yashiro, M., Hirakawa, K."Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma". Oncology Reports 21, no. 4 (2009): 875-880. https://doi.org/10.3892/or_00000297
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