Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report

  • Authors:
    • Tomoki Nakamura
    • Akihiko Matsumine
    • Hiroaki Kato
    • Katsuyuki Kusuzaki
    • Keisuke Nishimura
    • Tetsuya Murata
    • Taizo Shiraishi
    • Yoshinao Oda
    • Masazumi Tsuneyoshi
    • Atsumasa Uchida
  • View Affiliations

  • Published online on: April 1, 2009     https://doi.org/10.3892/or_00000299
  • Pages: 887-891
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Abstract

We present a case of malignant melanoma with a rhabdoid phenotype in a 44-year-old female with a quite unique and aggressive clinical course. Rhabdoid features are defined by characteristics such as sheets or solid trabeculae of neoplastic cells with large, vesicular, round to bean-shaped nuclei, prominent centrally located nucleoli, and abundant eccentric cytoplasm. Although various histological differential diagnoses were cited for the present case that showed ‘rhabdoid features’, most of them were excluded on the basis of the clinical history, tumor location, clinical behavior, and a broad panel of immunohistochemical stains. In the present case, the immunohistochemical findings were positive for vimentin, S-100 protein, melan-A, and EMA, but negative for HMB45, cytokeratin, CD34 and desmin. In addition, the positive expression of BAF47 was also recognized. These findings lead to the conclusion that this quite unique aggressive soft tissue tumor should therefore be diagnosed as malignant melanoma with a rhabdoid phenotype.

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April 2009
Volume 21 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nakamura T, Matsumine A, Kato H, Kusuzaki K, Nishimura K, Murata T, Shiraishi T, Oda Y, Tsuneyoshi M, Uchida A, Uchida A, et al: Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report. Oncol Rep 21: 887-891, 2009
APA
Nakamura, T., Matsumine, A., Kato, H., Kusuzaki, K., Nishimura, K., Murata, T. ... Uchida, A. (2009). Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report. Oncology Reports, 21, 887-891. https://doi.org/10.3892/or_00000299
MLA
Nakamura, T., Matsumine, A., Kato, H., Kusuzaki, K., Nishimura, K., Murata, T., Shiraishi, T., Oda, Y., Tsuneyoshi, M., Uchida, A."Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report". Oncology Reports 21.4 (2009): 887-891.
Chicago
Nakamura, T., Matsumine, A., Kato, H., Kusuzaki, K., Nishimura, K., Murata, T., Shiraishi, T., Oda, Y., Tsuneyoshi, M., Uchida, A."Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: A case report". Oncology Reports 21, no. 4 (2009): 887-891. https://doi.org/10.3892/or_00000299