Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development

  • Authors:
    • Yu-Mei Ding
    • Ji-Hua Dong
    • Li-Li Chen
    • Han-Dong Zhang
  • View Affiliations

  • Published online on: April 1, 2009     https://doi.org/10.3892/or_00000312
  • Pages: 983-987
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Abstract

Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development. Immunohistochemistry, Western blotting and RT-PCR were carried out in 62 primary OSCC, 38 oral leukoplakia (OPL) tissues to detect the Gal-1 expression in both protein and mRNA levels. Ten normal oral mucosa (NOM) tissues were used as control. Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). In accordance with Gal-1 protein, Gal-1 mRNA was also up-regulated in OSCC tissues and OPL tissues. Furthermore, both the Gal-1 protein and mRNA in OSCC tissues were higher than in OPL tissues (P<0.05). Our data supports the important roles of Gal-1 in OSCC development and suggests that Gal-1 upregulation in the OSCC and OPL tissues might be a predictor of early oral carcinogenesis.

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April 2009
Volume 21 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ding Y, Dong J, Chen L and Zhang H: Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development. Oncol Rep 21: 983-987, 2009.
APA
Ding, Y., Dong, J., Chen, L., & Zhang, H. (2009). Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development. Oncology Reports, 21, 983-987. https://doi.org/10.3892/or_00000312
MLA
Ding, Y., Dong, J., Chen, L., Zhang, H."Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development". Oncology Reports 21.4 (2009): 983-987.
Chicago
Ding, Y., Dong, J., Chen, L., Zhang, H."Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development". Oncology Reports 21, no. 4 (2009): 983-987. https://doi.org/10.3892/or_00000312